Leukaemia

Question 1 of 40

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Define leukamia

Select one of the following:

  • Neoplastic proliferation of haemopeoietic or lymphoid cells

  • Neoplastic proliferation of lymphoid cells

  • Neoplastic proliferation of bone marrow

Question 2 of 40

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In acute leukaemia, abnormality occurs in mature cells

Select one of the following:

  • True
  • False

Question 3 of 40

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Acute leukaemia is described as a block in differentiation

Select one of the following:

  • True
  • False

Question 4 of 40

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Acute leukaemia is caused by acute proliferation of...

Select one or more of the following:

  • Myeloblasts

  • Lymphoblasts

  • Both (rare)

  • Both (most common)

Question 5 of 40

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What are the symptoms of chronic leukaemia?

Select one or more of the following:

  • No block in differentiation

  • Block in differentiation

  • Low proliferation

  • High proliferation

Question 6 of 40

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Acute leukaemia is recognised by a certain type of cell being up to 50% of bone marrow cells?

Select one of the following:

  • Blasts

  • Reticulocytes

  • Lympocytes

Question 7 of 40

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In A.L, there are often reticulocytes in the peripheral blood

Select one of the following:

  • True
  • False

Question 8 of 40

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Leukaemia is caused by clonal proliferation from a single cell

Select one of the following:

  • True
  • False

Question 9 of 40

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How can you (sometimes) differentiate between a myeloblast and a lymphoblast?

Select one or more of the following:

  • Myeloblasts have auer rods

  • Lymphoblasts have auer rods

  • Myeloblasts have a large, pale nucleus

  • Lymphoblasts have a large, pale nucleus

Question 10 of 40

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MUD stands for

Select one of the following:

  • Matched Unrelated Donor

  • Myeloblast Unknown Death

  • Myeloblasts Under Duress

Question 11 of 40

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Remission - no disease in the blood

Select one of the following:

  • True
  • False

Question 12 of 40

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Why use the Minimal Residual Disease (MUD)?

Select one of the following:

  • Assess chances at relapse/need for further treatment

  • Assess effectiveness of drug

  • Prevent remission

Question 13 of 40

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BMT - Bone Marrow Transplant

Select one of the following:

  • True
  • False

Question 14 of 40

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B Cell Acute Lymphoblastic Leukaemia has a poor prognosis for children but a good one for adults

Select one of the following:

  • True
  • False

Question 15 of 40

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Which of the following is has the poorer prognosis

Select one of the following:

  • Acute T-Cell Precursor Lymphoblastic

  • Acute B-Cell Precursor Lymphoblastic

Question 16 of 40

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What is found in cytogenetic testing of ALL?

Select one of the following:

  • Hyperploidy

  • Aneuploidy

  • Nullosomy

Question 17 of 40

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Which of the following are found in ALL cytochemistry?

Select one or more of the following:

  • MPX/SB are neg

  • MPX/SB are pos

  • PAS block pos

  • PAS block neg

Question 18 of 40

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Which of the following are found in Immunophenotyping for ALL?

Select one or more of the following:

  • CD19

  • CD7

  • CD10

Question 19 of 40

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What is true of AML?

Select one or more of the following:

  • Inc WBC

  • Dec RBC

  • Dec Plateles

  • Inc RBC

  • Inc Platelets

Question 20 of 40

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AML means there is no normal cells

Select one of the following:

  • True
  • False

Question 21 of 40

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What markers are used in Flow Cytometry to identify AML?

Select one or more of the following:

  • CD13

  • CD33

  • CD12

  • CD4

Question 22 of 40

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AML is more common in adult women

Select one of the following:

  • True
  • False

Question 23 of 40

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When is AML called 'De Novo'

Select one of the following:

  • When it occurs for the first time

  • If it occurs secondary to other malignancies

  • If it never relapses

Question 24 of 40

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Which of the following is common in AML (as opposed to ALL)

Select one of the following:

  • CNS leukaemia

  • Lymph, spleen and gum problems

  • Lymphodenopathy

Question 25 of 40

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Match up the following- A = Fatigue, B= Fever/Infections, C= Spontaneous Bruising
1 = Low Platelets 2= Low Hb 3 = Low WBC

Select one of the following:

  • A2, B3, C1

  • A1, B2, C3

  • A3 B2 C1

Question 26 of 40

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CML- accumulation of mature myeloid cells

Select one of the following:

  • True
  • False

Question 27 of 40

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Genetic anomalies in CML occur low down where they effect cells

Select one of the following:

  • True
  • False

Question 28 of 40

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What happens in 95% of cases to cause AML?

Select one or more of the following:

  • Chromosome 22 shortens

  • Linking BCR & ABL genes together

  • Chromosome 22 inverts

  • Chromosome 22 lengthens

Question 29 of 40

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In indentifying CML, immunophenotyping is useless

Select one of the following:

  • True
  • False

Question 30 of 40

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CML is more common in adult men

Select one of the following:

  • True
  • False

Question 31 of 40

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What is the WBC in CML?

Select one of the following:

  • >50 x 10^9/l

  • <30 x 10^9/l

  • >75 x 10^9/l

Question 32 of 40

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What will be found in a CML bone marrow sample?

Select one or more of the following:

  • Bone marrow is hypercellular

  • Bone marrow is hypocellular

  • Myeloid cells are present at all developmental stages

  • Inc Neutraphil Alkaline Phosphatase

  • Red Neutraphil Alkaline Phosphatase

Question 33 of 40

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Glivec stops CML cells dividing, but is expensive

Select one of the following:

  • True
  • False

Question 34 of 40

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CLL- Neoplastic proliferation of mature looking lymphocytes

Select one of the following:

  • True
  • False

Question 35 of 40

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What ususally happens in CML?

Select one of the following:

  • Lymphoids form masses in the bone marrow, spleen and lymph nodes

  • Lymphoids lyse and release contents as they are made poorly

  • Lymphs begin attacking body cells

Question 36 of 40

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In CLL, the lymph population can be over 300x the normal

Select one of the following:

  • True
  • False

Question 37 of 40

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What are smear cells?

Select one of the following:

  • Cells that rupture during a smear

  • Cells so malleable they look like smudges

  • Cells so deformed they form masses, which look like smears

Question 38 of 40

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In CLL, the bone marrow is <25% lymphocytes

Select one of the following:

  • True
  • False

Question 39 of 40

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What does immunophenotyping in CLL tell us?

Select one or more of the following:

  • Clonality

  • Which lymph cells they are

  • The markers

Question 40 of 40

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CLL is more common in old men

Select one of the following:

  • True
  • False
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gina_evans0312
Quiz by , created almost 3 years ago

Haematology and Anatomy (Leukocytes) Quiz on Leukaemia, created by gina_evans0312 on 09/01/2014.

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Created by gina_evans0312 almost 3 years ago
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