Coagulation and Coagulation Disorders

Question 1 of 36

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The Extrinsic Pathway operates on the initiating cell

Select one of the following:

  • True
  • False

Question 2 of 36

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What is the role of the Extrinsic Pathway?

Select one of the following:

  • Coagulation initiation

  • Formation of the fibrin plug

  • Activation of Factor V

Question 3 of 36

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The Intrinsic Pathway works on...

Select one of the following:

  • The endothelium

  • The vW factor

  • The platelet surface

Question 4 of 36

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The Intrinsic pathway is designed to generate thrombin bursts

Select one of the following:

  • True
  • False

Question 5 of 36

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Name the three steps of Coagulation

Select one or more of the following:

  • Initiation

  • Amplification

  • Propagation

Question 6 of 36

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What begins the Initiation phase?

Select one of the following:

  • Vascular injury initiates trigger factor

  • Vascular injury exposes collagen for platelets to bind

  • Vascular injury causes blood cells to lyse

Question 7 of 36

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Trigger factor activates VII, which activates smal amounts of

Select one or more of the following:

  • IX

  • X

  • XI

Question 8 of 36

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X & XI bind to platelets and produce small amounts of Thrombulin

Select one of the following:

  • True
  • False

Question 9 of 36

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Thrombin initiates Amplification

Select one of the following:

  • True
  • False

Question 10 of 36

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The platelets act as a surface for the assembly of what factor complexes?

Select one or more of the following:

  • IX & VIII

  • Prethrombinase (X & V)

Question 11 of 36

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What happens in Propogation

Select one of the following:

  • Activated platelets/complexes generate Thrombin Burst

  • Activated platelets/complexes generate Thrombulin Burst

  • Activated platelets/complexes generate Thromblin Burst

Question 12 of 36

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What two things are required for Fibrin Clot formation?

Select one or more of the following:

  • Fibrinogen --> Fibrin

  • F IIa

  • F III

  • F V

Question 13 of 36

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Thrombin production is the crucial step in haemostasis

Select one of the following:

  • True
  • False

Question 14 of 36

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The first step in Coagulation Disorder diagnosis is a family & drug history

Select one of the following:

  • True
  • False

Question 15 of 36

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Name the two main clinical presentation of coagulation disorders

Select one or more of the following:

  • Bleeding in deep tissues

  • Bleeding in joints

  • Flushed skin

  • Easy cutting of skin

Question 16 of 36

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Prethrombin Time is anassessment of the _ Pathway

Select one of the following:

  • Extrinsic

  • Instrinsic

Question 17 of 36

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Prethrombin time is expressed as an international, normalised ratio

Select one of the following:

  • True
  • False

Question 18 of 36

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Activated Partial Thromboplastin Time is an indicator of...

Select one of the following:

  • Intrinsic pathway

  • Extrinsic pathway

Question 19 of 36

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Which of the following are not Coagulation Disorder investigations?

Select one of the following:

  • Fibrinogen Assay

  • FXIII Screen

  • Thrombin Clotting Time

  • Fibin Clotting Time

Question 20 of 36

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How do you evaluate increased prethrombin time?

Select one or more of the following:

  • Mix with normal platelets (50:50)

  • Remove half the platelets from a sample

  • Then a Factor VII assay

Question 21 of 36

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How do you evaluate Activated Partial Thromboplastin Time (APPT)?

Select one or more of the following:

  • Mix with normal plasma

  • Then do a Factor VIII, IX, XI assay

  • Then a FXII assay

Question 22 of 36

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Lack o Factor X causes no symptoms

Select one of the following:

  • True
  • False

Question 23 of 36

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Factor I assay is used if bot PT and APTT is elevated

Select one of the following:

  • True
  • False

Question 24 of 36

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If both PT and APTT is normal, what is tested for?

Select one or more of the following:

  • Factor XIII

  • TCT

  • Factor X

Question 25 of 36

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Aquired Coagulation Deficiencies are caused by a lack of what?

Select one of the following:

  • Vit A

  • Vit B

  • Vic D

  • Vit K

Question 26 of 36

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What can cause Aquired Vit K deficiency?

Select one of the following:

  • DIC

  • Massive Transfusion Effect

  • Malabsorption

Question 27 of 36

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Vit-K deficiency can be drug induced i.e. in the case of liver disease

Select one of the following:

  • True
  • False

Question 28 of 36

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Haemophilia A is caused by what?

Select one of the following:

  • Factor VIII deficiency

  • Factor VI deficiency

  • Factor V deficiency

Question 29 of 36

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Haemophilia A is sex linked

Select one of the following:

  • True
  • False

Question 30 of 36

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Haemophilia B is a Factor IX deficiency

Select one of the following:

  • True
  • False

Question 31 of 36

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The mutations for Haemophilia A & B are found on which chromosome?

Select one of the following:

  • X

  • Y

Question 32 of 36

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How do you identify Haemophilia B?

Select one of the following:

  • Inc PT

  • Inc APTT

  • Factor IX assay

Question 33 of 36

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Von Willebrands disease is caused by a lack of factor

Select one of the following:

  • VIII

  • VII

  • VI

Question 34 of 36

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vW disease is detected by

Select one or more of the following:

  • FVIII Assay

  • vWF assay

Question 35 of 36

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Since many things can effect the levels of vWF, testing is difficult

Select one of the following:

  • True
  • False

Question 36 of 36

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vW disease can be qualitative or quantitative

Select one of the following:

  • True
  • False
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Coagulation and Coagulation Disorders

gina_evans0312
Quiz by , created almost 3 years ago

Haematology and Anatomy (Coagulation) Quiz on Coagulation and Coagulation Disorders, created by gina_evans0312 on 09/01/2014.

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Created by gina_evans0312 almost 3 years ago
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