Fibrinolysis

Question 1 of 37

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The vascular endothelium protects platelets from subendothelial aggregating substances i.e. collagen

Select one of the following:

  • True
  • False

Question 2 of 37

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Vasoconstriction around injured site helps coagulation how?

Select one of the following:

  • Reduced blood flow decreases pressure and loss of blood

  • Reduced blood flow brings coagulation factors into tissue contact more readily

  • Reduced blood flow decreases wall diameter, decreasing size of breach

Question 3 of 37

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Why is Fibrinolysis necessary?

Select one of the following:

  • It prevents inappropriate extension of the fibrin plug

  • Prevents clotting from damaging nearby cell

  • Prevents clotting in case of infected blood

Question 4 of 37

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To prevent inappropriate prevention of coagulation, where are coagulation inhibitors limited to?

Select one or more of the following:

  • Intact endothelium

  • Breached endothelium

  • Free flowing blood

Question 5 of 37

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Inhibitors are triggered by late products of coagulation

Select one of the following:

  • True
  • False

Question 6 of 37

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What is inhibited by the Tissue Factor Pathway Inhibitor?

Select one of the following:

  • FX reversibly

  • FX permanently

  • FVII

  • FV

Question 7 of 37

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Anthithrombin deactivates several enzymes of the coagulation system

Select one of the following:

  • True
  • False

Question 8 of 37

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Protein S & C work the same way

Select one of the following:

  • True
  • False

Question 9 of 37

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The Protein C pathway is initiated by what?

Select one or more of the following:

  • Thrombin

  • Antithrombomodulin

  • Antithrombin

Question 10 of 37

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Thrombomodulin works in the free flowing blood

Select one of the following:

  • True
  • False

Question 11 of 37

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Both thrombin and thrombomodulin work on the endothelial cell surface

Select one of the following:

  • True
  • False

Question 12 of 37

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What is the role of thrombomodulin?

Select one of the following:

  • Conversion of Thrombin to Antithrombin

  • Conversion of Thrombin to a Coagulation Inhibitor

  • Removal of platelets

Question 13 of 37

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Excess thrombin binds to thrombomodulin on intact cells, which allows it to be altered

Select one of the following:

  • True
  • False

Question 14 of 37

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Protein C acts as an anticoagulant by degrading Factors

Select one or more of the following:

  • V

  • VIII

Question 15 of 37

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Protein C needs Mg in order to function

Select one of the following:

  • True
  • False

Question 16 of 37

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Which of the following support Protein C activity?

Select one or more of the following:

  • Protein S

  • Inactive F V

  • Active F V

Question 17 of 37

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60% of patients with thrombophilia have a

Select one of the following:

  • Factor II deficiency

  • Protein C deficiency

  • Protein S deficiency

Question 18 of 37

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VTE = Venous Thromboembolism

Select one of the following:

  • True
  • False

Question 19 of 37

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What is thrombosis?

Select one of the following:

  • An increased liklihood of spontaneous clotting

  • An inability to form blood clots

Question 20 of 37

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Name the risk factors for thrombophilia

Select one or more of the following:

  • Alteration in blood components i.e. pregnancy

  • Circulatory stasis i.e. venous problems

  • Artificial surfaces i.e. a STENT

Question 21 of 37

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VTE occurs when blood coagulation overwhelms fibrogenlysis/anticoagulant mechanisms

Select one of the following:

  • True
  • False

Question 22 of 37

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Thrombophilia is linked to Lupus Anticoagulant Syndrome

Select one of the following:

  • True
  • False

Question 23 of 37

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Name some examples where Anticoagulation therapy is necessarry

Select one or more of the following:

  • Patient with a myocardial infarction (MI)

  • Patients with Lupus/APS

  • Deep Vein Thrombosis/ Primary Embolism

Question 24 of 37

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How is Heparin administered?

Select one or more of the following:

  • Intravenously

  • Subcutaneously

  • Ingestion

Question 25 of 37

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How does Heparin work?

Select one of the following:

  • Increases action of Antithrombin

  • Increases Protein C activity

  • Increases degredation of platelets

Question 26 of 37

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Why is Low Molecular Weight Heparin better?

Select one or more of the following:

  • 100% bioavalibility

  • Longer half life

  • Less frequent osteoporosis

Question 27 of 37

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Dabigatran is only used in cases of Atrial Fibrilation

Select one of the following:

  • True
  • False

Question 28 of 37

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Dabigatran is a FX inhibitor, Rivaroxabin is a thrombin inhibitor

Select one of the following:

  • True
  • False

Question 29 of 37

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Warfarin works how?

Select one of the following:

  • Directly inhibits thrombin

  • Inhibits Vit K metabolism

  • Lyses platelets

Question 30 of 37

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Without Vitamin K, why is coagulation so much slower?

Select one or more of the following:

  • Non carboxylated factors cannot bind to Ca2+

  • Non carboxylated factors cannot bind to phosphorylated

  • Non carboxylated factors cannot be inhibited

Question 31 of 37

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Warfarin is used when all four clotting factors are low

Select one of the following:

  • True
  • False

Question 32 of 37

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What is the leading dose of Warfarin?

Select one of the following:

  • 6mg for 3 days

  • 3mg for 6 days

Question 33 of 37

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What test is used to monitor warfarin activity?

Select one of the following:

  • Prethrombin time

  • Activated Partial Thromboplastin Time

  • Fibrin Assay

Question 34 of 37

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What is the reference for Prethrombin Time?

Select one or more of the following:

  • Standard reference thromboplastin

  • Potency is ISI- International Sensitivity Index

  • Standard reference antithrombin

Question 35 of 37

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INR = Prethrombin Time/ Mean Normal Prethrombin Time

Select one of the following:

  • True
  • False

Question 36 of 37

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Match the dangerous INR ranges-
A= (2-3)
B= (3-4)

Select one of the following:

  • A= Prosthetic Heart Valves
    B = DVT

  • A = DVT
    B = Prosthetic Heart Valves

Question 37 of 37

Medal-premium 1

When using Warfarin, stop if the INR <2 for two consecutive days

Select one of the following:

  • True
  • False
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Fibrinolysis

gina_evans0312
Quiz by , created almost 3 years ago

Haematology and Anatomy (Coagulation) Quiz on Fibrinolysis, created by gina_evans0312 on 10/01/2014.

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Created by gina_evans0312 almost 3 years ago
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