When the LDL first binds to the receptor, what is internalised?
The bound receptor
An uncoated clathrin vesicle has lost the clathrin it was previously coated with
What happens to the LDL receptors once they've been internalised?
They're removed the vesicle and returned to the cell surface
They're removed the vesicle and destroyed
They're removed the vesicle and altered into different receptors
How is the LDL broken down?
Inc in protease concentration
LDL's are broken down into amino acids, fatty acids and triacylglycerols
Fatty acid oxidation is done in the mitochondria
The cleavage of 2C from a fatty acid chain does what?
Releases oxidative energy
Releases 2C for substrate dependent oxidation
VDL's are created in the small intestine, chylomicrons in the liver
Name the two enzymes that allow lipids to be removed from lipoproteins for use in the cell
Lecithin-Cholesterol Acetyl Transferase
Removal of lipids from fatty acids leave remenants behind in the blood
Two things can happen to these remnants, what are they?
Uptake into cells for conversion into other lipoproteins
Conversion to LDL's in the blood
Conversion to VDL's in the intestines
What is the role of the Overflow Pathway?
Conversion of LDL's into HDL's so they can be returned to the liver
Conversion of remnants to LDL's that stick to arterial walls
Conversion of Chylomicrons to VLDL