NSAIDs

Question 1 of 21

Medal-premium 1

Why are some NSAIDs known as 'Traditional'?

Select one of the following:

  • They only block one COX

  • The block both COXs

Question 2 of 21

Medal-premium 1

Describe COX1

Select one or more of the following:

  • Constituative

  • Inducible

  • Membrane bound

  • Cytoplasmic

Question 3 of 21

Medal-premium 1

The channels of both COX1 & COX 2 are constricted to prevent incorrect substrate binding

Select one of the following:

  • True
  • False

Question 4 of 21

Medal-premium 1

Where do NSAIDs bind on COX 1?

Select one of the following:

  • Arg 120

  • Arg 130

  • Arg 140

Question 5 of 21

Medal-premium 1

Aspirin binds permenantly to the Ser 530 of COX1

Select one of the following:

  • True
  • False

Question 6 of 21

Medal-premium 1

Why does COX2 have a much wider channel than COX 1?

Select one of the following:

  • Val533 forces the channel to be wider

  • Ser533 forces the channel to be wider

  • Ile533 forces the channel to be wider

Question 7 of 21

Medal-premium 1

COX2 is inducible

Select one of the following:

  • True
  • False

Question 8 of 21

Medal-premium 1

The smaller channel of COX2 can be used for selective inhibition- i.e. Colecoxib

Select one of the following:

  • True
  • False

Question 9 of 21

Medal-premium 1

COX2 is much less responsible for inflammation than COX1

Select one of the following:

  • True
  • False

Question 10 of 21

Medal-premium 1

Why are selective COX2 inhibitors used on patients with G.I troubles?

Select one of the following:

  • They also repair mucus membranes

  • They have fewer side effects

  • They cannot be digested properly by healthy tracts

Question 11 of 21

Medal-premium 1

What is the most common side effect of NSAIDs?

Select one of the following:

  • GI troubles

  • Renal insufficiency

  • C.V disorders

Question 12 of 21

Medal-premium 1

Aspirin is the only NSAID thought not to cause cardiovascular disorders

Select one of the following:

  • True
  • False

Question 13 of 21

Medal-premium 1

Name the two NSAID side effects that contribute to cardiovascular disorders

Select one or more of the following:

  • Inc salt and water retention

  • Constant vasoconstriction effect endothelium

Question 14 of 21

Medal-premium 1

Cole/Paracoxib are traditional NSAIDs

Select one of the following:

  • True
  • False

Question 15 of 21

Medal-premium 1

What is the effect of Aspirin in platelets?

Select one of the following:

  • Reduced Thromboxin A2

  • Reduced Thromboxin I2

  • Reduced Thromboxin E2

Question 16 of 21

Medal-premium 1

The binding of aspirin lasts for the entire life of the platelet

Select one of the following:

  • True
  • False

Question 17 of 21

Medal-premium 1

To whom can Aspirin not be given?

Select one or more of the following:

  • Over 65s

  • Pregnant women

  • Children under 16

Question 18 of 21

Medal-premium 1

Paracetamol is anti-inflammatory but not antipyretic

Select one of the following:

  • True
  • False

Question 19 of 21

Medal-premium 1

The action of paracetamol is unknown

Select one of the following:

  • True
  • False

Question 20 of 21

Medal-premium 1

Why is paracetamol toxic to the liver in high doses?

Select one or more of the following:

  • Oversaturates the removal pathway

  • Causing an alternative to be used

Question 21 of 21

Medal-premium 1

The alternative paracetamol removal pathway causes an increase in toxic NAPQ1

Select one of the following:

  • True
  • False
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gina_evans0312
Quiz by , created almost 3 years ago

Year 2 Quiz on NSAIDs, created by gina_evans0312 on 30/01/2014.

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gina_evans0312
Created by gina_evans0312 almost 3 years ago
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