Pre-Proinsulin contains an R.E.R signal that moves it to the golgi
What is the role of the C-peptide part of the insulin chain
Formation of disulphide bonds between the alpha and beta chains
Formation of Fe-S bonds between the alpha and beta chains
Formation of peptide bonds between the alpha and beta chains
Pro-insulin is made of the alpha & beta chains and the c peptide
Which of the following cleave the c-peptide from the proinsulin?
What form does newly made insulin take?
The cleaved C-peptide is released along with the insulin
Why do Mannoheptulases inhibit insulin release?
The insulin secretion system relies on the phosphorylation of glucose, which MHLs inhibit
MHLs block excretory channels
MHLs prevent the movement of insulin to the RER
Optimum insulin secretion occurs at 8mM
Why is optimal secretion of insulin at 8mM
GLUT 2 & glucokinase have Kms of 8
Not gonna put anything else
Insulin secretion relies on ATP dependent K+ channels
K+ buildup causes Ca2+ influx and insulin secretion
Which drugs block K+ channels and mimic high glucose?
Diazoxide causes insulin secretion by keeping channels open
High doses of adrenaline stimulates insulin secretion through _ receptors
Low concs of adrenaline inhibit insulin secretion through Beta receptors
Insulin is catabolic
Insulin stimulates _ activity in order to reduce cAMP levels
Which of the following metabolites are reduced?
Fatty Acyl CoA
Inc. Phosphorylation of tyrosine kinase by insulin causes what?
Inc tyrosine kinase activity
Inc phosphatase activity
Inc Adenylate cyclase activity