Antigen Presentation

Question 1 of 22

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B Cells recognise native antigens, T cells recognise processed antigens

Select one of the following:

  • True
  • False

Question 2 of 22

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Which of the following are NOT professional antigen presenting cells?

Select one of the following:

  • Neutrophils

  • Macrophages

  • Dendritic cells

Question 3 of 22

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CD8 T-cells recognise which MHC complex?

Select one of the following:

  • MHCI

  • MHCII

Question 4 of 22

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CD4 is for the detection of virally infected cells

Select one of the following:

  • True
  • False

Question 5 of 22

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CD4 cells recognise MHCII, which uses which Antigen processing system?

Select one of the following:

  • Endosomal

  • Endogenous

  • Endomal

Question 6 of 22

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Cells with MHCI present using the endogenous AP system

Select one of the following:

  • True
  • False

Question 7 of 22

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T- cells cannot recognise soluble, native antigens

Select one of the following:

  • True
  • False

Question 8 of 22

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Put the following steps in the correct order- A (Antigen-MHC Complex Formation), B (Uptake), C (Presentation) and D (Degredation

Select one of the following:

  • B-D-A-C

  • A-B-D-C

  • A-C-B-D

Question 9 of 22

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Which of the following definitions is incorrect?

Select one of the following:

  • Uptake- picking up of the antigen from surrounding fluid

  • Degredation- total digestion of the antigen

  • Presentation- movement of the complex to the cell surface

Question 10 of 22

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Endosomal Pathway- What is it for?

Select one of the following:

  • Processing of extracellular antigens picked up by antigen presenting cells

  • Processing of cytosolic viral antigens

Question 11 of 22

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Endosomal Pathway- Uses the MHCI complex

Select one of the following:

  • True
  • False

Question 12 of 22

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Endosomal Pathway- The extracellular antigen is picked up by phagocytosis

Select one of the following:

  • True
  • False

Question 13 of 22

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Endosomal Pathway- How is picking up of the antigen mediated?

Select one or more of the following:

  • Receptor mediated

  • Compliment mediated

  • Hormone mediated

Question 14 of 22

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Endosomal Pathway- The antigen containing endosome only binds to the MCHII containing endosome after partial digestion

Select one of the following:

  • True
  • False

Question 15 of 22

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Endosomal Pathway- How is the active site of MHCII covered in the cell?

Select one of the following:

  • Covered by an invariant 'cap'

  • The two parts are connect by a subunit that must be removed

  • Receptor surface is bound to the endosome envelope

Question 16 of 22

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Endosomal Pathway- The cover of the MHC complex is called a CLIP

Select one of the following:

  • True
  • False

Question 17 of 22

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Endosomal Pathway- How is the processed antigen added to the MHCII complex?

Select one of the following:

  • Acessory proteins swap the CLIP for the peptide when the two vesicles fuse

  • Acessory proteins remove the MHCII from the envelope when the two vesicles fuse

  • Acessory proteins remove the subunit connecting the two halves when the two vesicles fuse

Question 18 of 22

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Endogenous Pathway- Main use is for what?

Select one of the following:

  • Viral antigen processing

  • Professional pesentation of antigens

Question 19 of 22

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Endogenous Pathway uses MHCII

Select one of the following:

  • True
  • False

Question 20 of 22

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Endogenous Pathway- How are cytosolic antigens processed?

Select one of the following:

  • By the TCR

  • By MHCI

  • By cytosolic proteases

Question 21 of 22

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Endogenous Pathway- Digested peptides are moved into the Golgi by what?

Select one of the following:

  • Transporter Associated with Antigen Processing (TAP 1&2)

  • Transporter Associated with Antigen Digestion (TAD 1&2)

  • Transporter Associated with Antigen Presentation (TAP 1&2)

Question 22 of 22

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In the Golgi the processed peptide is bound to MHCI and they complex is loaded into a vesicle for transport to the cell membrane

Select one of the following:

  • True
  • False
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Antigen Presentation

gina_evans0312
Quiz by , created over 2 years ago

Year 2 Quiz on Antigen Presentation, created by gina_evans0312 on 13/03/2014.

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Created by gina_evans0312 over 2 years ago
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