in osteogenesis imperfecta (brittle bone disease) what faulty collagen process is affected?
What are the 4 main results of osteogenesis imperfecta mutations?
(often missense point mutations resulting in substitution of glycine)
Which would be more severe for O.I sufferers. A mutation in α1 or a mutation of the α2 stand of the type 1 collagen helix?
What are the three factors that determine the severity of OI?
What is gonadal mosaicism?
Defect in what causes junctional epidermolysis bullosa?
Defects in what cause dystrophic epidermolysis bullosa?
What happens to collagen in scurvy?
What happens in chondrodysplasia?
What causes lathyrism?
What is osteoarthritis caused by?