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Neuromuscular Junction

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O usuário eliminou as informações de disciplina Mapa Mental sobre Neuromuscular Junction, criado por Usuário eliminado em 21-01-2018.
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Plymouth Med
Criado por Plymouth Med quase 9 anos atrás
Plymouth Med
Copiado por Plymouth Med quase 9 anos atrás
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Resumo de Recurso

Neuromuscular Junction
  1. Terminal Axon
    1. Motor End Plate of Muscle Fiber
      1. 4) Receptors open up ligand-gated cation channels
        1. 5) Depolarization of sarcolemma membrane via t-tubules
          1. Sodium ions enter muscle fiber
            1. Potassium ions leave muscle fiber
              1. goes from -70 mv--> +40 mv
                1. 6) Action potential fired along length of the muscle fiber
                  1. travels length of the myotube
            2. Muscle fiber/myotube
              1. Sarc. Reticulum
                1. Storage of calcium ions
                  1. Resting muscle = HIGH [Calcium]
                    1. ATP-fueled CA2+ pumps/channels
                  2. Sarcoplasm (membrane)
                      1. Myofibril
                        1. Made of 2 myofilaments
                          1. Cross Bridge Interaction
                            1. Actin
                              1. Has myosin binding sites
                                1. Thick strand
                                2. Myosin
                                  1. Double Headed, Thin strand
                                    1. covered by Tropomyosin
                                      1. Calcium binding sites
                                      2. Myosin heads activated via ATP
                                        1. ATP from Creatine Phosphate
                                          1. most abundant source of ATP for skeletal muscles
                                            1. Enzyme Creatine Kinase
                                              1. Break phosphates into ATP
                                                1. Build ATP back up together
                                              2. Break it into ADP and P
                                                1. Muscle chance to relax until ATP formed again
                                    2. t-tub
                                      1. 7) take action potential deep into the individual muscle cells
                                        1. 8) Causes sarcoplasmic Reticulum to release calcium into sarcoplasm
                                          1. DHP receptors cause release of calcium
                                            1. DHP--> voltage-dep calcium channel
                                            2. 9) Calcium rushes off and binds to tropomyosin
                                              1. Conformational Change
                                                1. 10) Tropomyosin moves away
                                                  1. 11) Actin binds to Myosin
                                                    1. Actin pulls itself along= MUSCLE CONTRACTION
                                                      1. Contraction END: when Calcium ions actively transported back to sarcoplasmic reticulum
                                    3. Neuron
                                      1. 1) Action Potential arrives From Neuron
                                        1. 2) CA 2+ ions diffuse into the dendrite
                                          1. go into presynaptic end
                                            1. via open voltage-gated calcium channels
                                            2. Calcium influx
                                              1. synaptic vesicles ready to fire AcH
                                                1. AcH released into the synaptic cleft
                                                  1. released via exocytosis
                                                    1. 3)Diffuses across and binds to receptors on motor end plate
                                                      1. presynaptic AcH binding--> + feedback loop
                                                        1. preps more Ach release
                                                          1. sustain/more muscle contraction
                                                            1. AcH removal
                                                              1. Reuptake
                                                                1. Diffuses back across cleft
                                                                2. Broke down
                                                                  1. Acetylcholinesterase
                                                                    1. Acetyl Acid
                                                                      1. Choline
                                                2. All muscle types use calcium and ATP for contraction

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