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13120118
Urinary Bladder Carcinoma
Descrição
Mapa Mental sobre Urinary Bladder Carcinoma, criado por yousaf alabrash em 04-04-2018.
Mapa Mental por
yousaf alabrash
, atualizado more than 1 year ago
Mais
Menos
Criado por
yousaf alabrash
mais de 8 anos atrás
18
0
0
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Resumo de Recurso
Urinary Bladder Carcinoma
signs and symptoms
hematuria
physiology of hematuria
initial
Urethra
total
bladder or upper UT
end
Bladder neck or prostate urethra
causes: differential diagnosis
pain
UTI
stones
without pain
glomerulonephritis
schistosomiasis
either
UTI
APCKD
Grading
urgency
frequency
weight loss and fatigue
peripheral swelling
causes
schistosoma
chronic cystitis
HPV
smoking
risk factors
occupational
aniline
Taxi drivers
Past exposure to radiation
type 2 diabetes treatment
prognosis (5 year)
stage 0
98%
stage 2
63%
stage 4
15%
overall survival
5 year: 77%
10 year: 70%
15 year: 65%
ALWAYS follow up with transurethral removal of bladder tumor (TURBT)
stage 1
88%
stage 3
46%
diagnosis
imaging
US
Cytoscopy
histopathology
grading
high grade
well differentiated
low grade
poorly differnentiated
staging
stage 0
cis
flat on the mucosal linning
Papillary 0a
Papillary on mucosal linning
stage 1
invades the submucosa
stage 2
invade the muscle layer
stage 3
invades the surrounding fat
stage 4
invade the surrounding tissues
cytology
Detect highly malignant cells (like CIS)
schistoma hematobium egges
Papillary varient
lab investigations
PSA
test for prostatic cancer and BPH
can cause UTI symptoms
normal level: up to 4ng/ml of blood
other investigations were disscussed in details in previous PBL's
management
stage 0
a(papillary)
mitomyocin
in situ
BCG
stage 1
low grade
BCG
high grade
radical cystectomy
stage 2 & 3
radical cystectomy
stage 4
chemotherapy
Physiology of micturation
during bladder filling
sympathetic (L1-L3) dominate
Relax detrusor muscle
stimulate the internal sphincter
during bladder emptying
parasympthatic (S2-S4) dominate
contract detrusor muscle
inhibit the internal sphincter
there must be somatic relaxation of external sphincter in order of voiding to happen
by pudendal nerve (S3-S4)
epidemiology
MC malignancy in UTI
9th MC malignancy
types
urothelial
in america and europe
MC risk factor: smoking
non-urothelial
in middle east
MC risk fsctor: schistosoma hemabotium
A cestode parasitic infection
increases carcinogen-metabolizing enzymes
+++N-nitrosamines
alkylating DNA damage
metaplasia and carcinoma
Anexos de mídia
Picture1 (binary/octet-stream)
Picture1 (binary/octet-stream)
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Picture2 (binary/octet-stream)
Urinary Bladder Papillary Lg1 (binary/octet-stream)
Urothelial Carcinoma High Grade Bladder 7 Ub006 1 (binary/octet-stream)
Picture7 (binary/octet-stream)
Picture6 (binary/octet-stream)
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