163154
Descrição
Mapa Mental por Shannon Grady, atualizado more than 1 year ago
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Criado por Shannon Grady
quase 11 anos atrás
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Postreceptor Events
- Ion Channel
- Lies across membrane
- Results from change in ion concentration within cell
- Ex: acetylcholine and nicotinic receptor
- Lies across membrane
- G-Protein Activation
- Guanine nucleotide-binding protein
- Activation of
G-protein on
cytoplasmic side of
membrane
- Open/close ion channel
- Stimulate second messenger
- cAMP
- calcium
- phosphoinositides
- cAMP
- Open/close ion channel
- Ex: acetylcholine and muscarinic receptors
- Guanine nucleotide-binding protein
- Tyrosine Kinase Stimulation
- Phosphorylates macromolecules
- Ex: insulin and peptide growth factors
- Phosphorylates macromolecules
- Penetration of Cell Membrane
- Drug must be very lipophilic to get through phospholipid bilayer
- Drug interacts directly with intracellular receptors
- Ex: steroids, sex hormones, thyroid hormones, statins
- Drug must be very lipophilic to get through phospholipid bilayer
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