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Transplantation

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Mapa Mental sobre Transplantation, criado por sam.hilton em 01-05-2013.
sam.hilton
Mapa Mental por sam.hilton, atualizado more than 1 year ago
sam.hilton
Criado por sam.hilton quase 13 anos atrás
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Resumo de Recurso

Transplantation
  1. Transplantable tissues
    1. Skin
      1. Kidnney
        1. Liver
          1. Heart
            1. Lung
              1. Pancreas
                1. Cornea
                  1. Bone Marrow
                    1. Face
                    2. Types
                      1. Autograft
                        1. Allograft
                          1. Isograft
                            1. Xenograft
                              1. Problems
                                1. Antibodies
                                  1. Hyperacute rejection
                                    1. Alpha1-3Gal
                                      1. transgenic pigs?
                                  2. Complement
                                    1. PERVS
                                2. Matching
                                  1. MHC
                                    1. MLR
                                      1. ABO
                                      2. Graft rejection
                                        1. Types
                                          1. Hyperacute
                                            1. ABO missmatch
                                              1. Pre existing antibodies
                                            2. Acute
                                              1. MHC missmatch
                                              2. Chronic
                                              3. T cell response
                                                1. Direct/indirect allorecognition
                                                2. Minor H antigens
                                                  1. MHC I
                                                    1. Polymorphic self proteins
                                                  2. GVHD
                                                    1. Immunosuppresive drugs
                                                      1. Cyclosporin A
                                                        2. Tacrolimus
                                                          1. Blocks calcineurin
                                                            1. dephosphorylation of NF-AT blocked
                                                              1. IL-2 blocked
                                                          2. Sirolimus
                                                            1. Binds mTOR
                                                              1. Prevents cell cycle in t cells
                                                            2. Side effects
                                                              1. Other drugs
                                                                1. Prednisone
                                                                  1. Azathioprine
                                                                    1. Anti-CD3 antibodies
                                                                      1. siRNA
                                                                        1. Tregs

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