Neurotransmitter

1. eprinephine

1. Synapse @ 1st sym
   1. --> ^or v paravert ganglion
      1. continue to prevertebral
         1. Extend or terminate @ adrenal medulla

1. α (1,2)
   1. Blood Vessel
      1. Heart
         1. Thrombocytes
            1. Bronchi
               1. Kidney
                  1. Adipocytes
                     1. Inhibit lipolysis
                     2. Lipolysis (triglycerides--> 3 fatty acid + glycerol
                  2. Vasoconstriction
                  3. Renin release (X tubular Na reabsorb)
               2. Dilation
            2. Aggregation
         2. ^ contractibility
      2. Constriction
      3. Dilation
2. β (1,2,3)

Anotações:

• mimic norepinephine and epinphrine

1. direct on a &β
2. indirectly on pre-syn terminal
3. Agonist
   1. X selective Adrenaline
      1. B P +
         1. Bronchi Dil
            1. Vasopressor

               Anotações:

               • +reduced BP
               1. Anaphlatic shock treatment

                  Anotações:

                  • a type of allergy, cause death
   2. α selective
      1. 1- nasal decongestant
         1. Phenylephrine
         2. Ephedrine
      2. 2 hypotensive drugs
         1. clonide
            1. methyldopa
   3. β 2
      1. Salbutamol

         Anotações:

         • Dilate bronchial smooth muscle used as aerosol for Asthma if not selective, +heart side effect
4. Antagonist
   1. β1
      1. Propanolol

         Anotações:

         • Side effect: Bronchial constriction CardioVascular app: H. fail,                                     Stage fright                                    Hypertension                                   Angina                                   Cardiac arhythmias
         1. Atenolol

1. on recpetor
   1. Muscarinic
      1. Pilocarpine

         Anotações:

         • Eye drop intraocular pressure - for glaucoma 青光眼
         1. Amanita Muscaria 菇

            Anotações:

            • BP v 口水 淚水 汗＋ adominal pain, nausea death due to H & lung failure