Autoimmunity

What are the effects of histamine at H1 receptors? Give an example of a drug that is used to treat inflammation?

What is 12-HETE?

Which prostaglandins are vasodilators?

What prostaglandins are vasoconstrictors?

What is the effect of thromboxane A2?

What is the effects of LTC4, LTD4 and LTE4?

What is the effect of LTB4?

Which prostaglandin predominates?

Describe the synthesis of PAF?

What is the role of PAF in asthma?

How are glucocorticoids linked to PAF?

How is bradykinin formed?

Describe B1 and B2 bradykinin receptors

What is the effect of NO? What happens when present in high levels?

What is sulfasalazine?

What are gold compounds?

what is anti cytokine therapy? What are the disadvantages?

What is infliximab?

What is basiliximab?

What is anakinara?

What is azathioprine?

What is copaxone?

What is peptide based immunotherapy?

Describe CD80 blocking drugs?

What is histamine synthesised from?

Where is histamine stored?

How is histamine releaed?

Give an example of a glucocorticoid

What do COX2 inhibitors reduce?

What happens in the COX enzyme in the absence of an inhibitor?

What is the role of CD80 and CD86 on APCs?

How do NSAID work?

How does MHC interact with the T cell receptor?

What two signals are required for the initiating of T cell activation?

What is the difference between the COX 1 and COX2 enzyme?

Describe delayed type hypersensitivity?

How are COX 2 selective drugs different to non selective ones?

Describe how insulin-dependent diabetes mellitus is caused?

What is the susceptibility factor for diabetetes mellitus?

What is the symptoms of diabetes mellitus?

What are the common side effects of NSAIDs?

What is cyclosporin and what is its effect?

How does cyclosporin inhibit IL-2 release?

Describe the disease mechanism of multiple sclerosis?

What are the symptoms of multiple sclerosis?

What are the susceptibility factors for MS?

what are the effects of glucocorticoids?

What is the mechanism of action for glucocorticoids?

What causes rheumatoid arthritis?

what are the susceptibility factors in rheumatoid arthritis?

How do infections contribute towards autoimmunity?

describe the Genetic susceptibility of autoimmune diseases?

Describe what happens in T cell mediated cytolysis?

Why do T-cells kill all infected cells?

Give an example of virally infected cytolysis?

what are the effects of prostaglandin?

What is the difference between the expression of COX1 and COX2?