Enzyme linked receptors

TKRs

PK casses

Binding to PK

GF R signalling

Insulin R signalling

Ras

+/- of Ras

Ras signal cascade

Insulin Receptor

Insulin R cascade

Why do this?

Enzyme -linked R

MOA (6)

Preferable drug design

The protein

Good/Bad targets?

Common target

Nuclear Receptors

Domain Structure:

Categorisation 1 based on MOA and distribution in cell when L absent (5)

Category 2

Category 2 diagram

Anti-hormone drugs