Matthew Coulson
Quiz por , criado more than 1 year ago

Psychosis and Schizophrenia lecture given on 15/10/2018. Includes neurobiology descriptions of antipsychotics.

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Matthew Coulson
Criado por Matthew Coulson aproximadamente 6 anos atrás
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Psychosis & Schizophrenia

Questão 1 de 34

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Brian believes that his parents are trying to poison him because the government are controlling them. Which psychopathology term is most appropriate?

Selecione uma das seguintes:

  • Grandiose delusion

  • Ideas of reference

  • Paranoid delusion

  • Auditory hallucination

  • loosening of associations

Explicação

Questão 2 de 34

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When Brian listens to the radio he can hear voices from elsewhere in the room telling him he must not think about the military information he has been given

Selecione uma das seguintes:

  • Functional hallucination

  • Gustatory hallucination

  • Passivity of thought

  • Thought insertion

  • Reactive affect

Explicação

Questão 3 de 34

1

Which of the following describes the belief that one's thoughts or actions are controlled by an external agent?

Selecione uma das seguintes:

  • Passivity of thought

  • Thought insertion

  • Reactive affect

  • Paranoid delusion

  • Loosening of associations

Explicação

Questão 4 de 34

1

Brian believes that news articles on the television about world leaders’ phones being tapped are actually talking about him as he holds important government information

Selecione uma das seguintes:

  • Nihilistic delusion

  • Ideas of reference

  • Flight of ideas

  • Auditory hallucination

  • Visual hallucination

Explicação

Questão 5 de 34

1

Schizophrenia is known to have a 78% heritability

Selecione uma das opções:

  • VERDADEIRO
  • FALSO

Explicação

Questão 6 de 34

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What is heritability?

Selecione uma das seguintes:

  • Likelihood of developing a trait if your monozygotic twin has it

  • Likelihood of developing a trait if your parent has it

  • Proportion of observable differences in a trait between individuals in a population that is due to genetic differences

  • Proportion of the range of genes involved in a multifactorial trait that you need to have in order to develop the trait

  • Likelihood of individuals with the trait having a genetic predisposition to it

Explicação

Questão 7 de 34

1

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Schizophrenia is known to be caused by viral illness in the ( 2nd, 1st, 3rd ) trimester of pregnancy

Explicação

Questão 8 de 34

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Taking heroin makes an individual very liable to drug-induced psychosis

Selecione uma das opções:

  • VERDADEIRO
  • FALSO

Explicação

Questão 9 de 34

1

Patients with schizophrenia tend to have enlarged ventricles in their brain

Selecione uma das opções:

  • VERDADEIRO
  • FALSO

Explicação

Questão 10 de 34

1

The reductions in cerebral grey matter seen in schizophrenia patients is attributable to reduced arborisation, which is ...

Selecione uma das seguintes:

  • Neuronal loss in grey matter

  • Reduced dendritic communication with other neurons due to fewer number of dendrites

  • Slowed neuronal conduction due to neuronal damage

Explicação

Questão 11 de 34

1

How many layers of grey matter exist in the brain?

Selecione uma das seguintes:

  • 6

  • 5

  • 9

  • 4

Explicação

Questão 12 de 34

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Things that cause an increase of ( dopamine, serotonin, noradrenaline ) in the brain are known to cause a psychotic state in humans.

Explicação

Questão 13 de 34

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Preencha o espaço em branco para completar o texto.

The mesolimbic pathway (reward system) originates in the area of the midbrain.

Explicação

Questão 14 de 34

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Blockade of dopamine receptors in the ( nigrostriatal, tuberoinfundibular, mesolimbic ) pathway can cause some of the symptoms associated with antipsychotics such as Haloperidol, for example dystonia, parkinsonian symptoms and akathisia

Explicação

Questão 15 de 34

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The Nigrostriatal Pathway originates in the ( Substantia Nigra, Lentiform Nucleus, Globus Pallidus, Putamen, Caudate Nucleus ) and projects to the Dorsal Striatum

Explicação

Questão 16 de 34

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Atypical Antipsychotic:
Typical Antipsychotic:

Arraste e solte para completar o texto.

    Haloperidol
    Quetiapine
    Phenytoin

Explicação

Questão 17 de 34

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Is olanzapine a typical or atypical antipsychotic?

Selecione uma das seguintes:

  • Typical

  • Atypical

Explicação

Questão 18 de 34

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( Atypical, Typical ) antipsychotics are more likely to cause metabolic syndrome as a side effect
( Typical, Atypical ) antipsychotics are more likely to cause extrapyramidal symptoms as a side effect

Explicação

Questão 19 de 34

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Selecione da lista do Menu para completar o texto.

The action of Haloperidol is antagonism of mainly ( dopamine, serotonin, alpha, histamine, noradrenaline ) receptors

Explicação

Questão 20 de 34

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The action of Olanzapine is mainly as an antagonist of ( serotonin, dopamine, noradrenaline, histamine, alpha ) receptors

Explicação

Questão 21 de 34

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Extrapyramidal side effects of typical antipsychotics are caused by a D2 blockade affecting which dopaminergic pathway?

Selecione uma das seguintes:

  • Mesolimbic pathway

  • Tuberoinfundibular pathway

  • Nigrostriatal pathway

Explicação

Questão 22 de 34

1

Match the extrapyramidal side effect to its description:
: Sudden onset painful involuntary muscle spasm, usually affecting the neck/back/eye
: Onset of tremor and muscle stiffness
: A feeling of inner restlessness and inability to stay still
: Involuntary, repetitive body movements (typically orofacial) that can include grimacing, sticking out the tongue or smacking the lips

Arraste e solte para completar o texto.

    Acute Dystonic Reaction
    Parkinsonism
    Akathisia
    Tardive Dyskinesia
    Drug-Induced Chorea

Explicação

Questão 23 de 34

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Which of the following extra-pyramidal symptoms typically takes years to develop (due to chronic antipsychotic use) and is very difficult to treat?

Selecione uma das seguintes:

  • Acute Dystonic Reaction

  • Parkinsonism

  • Akathisia

  • Tardive Dyskinesia

Explicação

Questão 24 de 34

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Some of the extrapyramidal side effects an be successfully treated using which one of the following medication types?

Selecione uma ou mais das seguintes:

  • Anticholinergics

  • Antidepressants

  • Anticonvulsants

  • Antiepileptics

Explicação

Questão 25 de 34

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Which two of the following extrapyramidal side effects can be easily treated via anticholinergic medications?

Selecione uma ou mais das seguintes:

  • Acute Dystonic Reaction

  • Parkinsonism

  • Akathisia

  • Tardive Dyskinesia

Explicação

Questão 26 de 34

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Dopamine Blockade also affects the tuberoinfundibular dopaminergic pathway, leading to a buildup of which pituitary hormone?

Selecione uma das seguintes:

  • Prolactin

  • Growth Hormone

  • LH

  • FSH

  • TSH

  • Oxytocin

  • Vasopressin

Explicação

Questão 27 de 34

1

Selecione da lista do Menu para completar o texto.

Hyperprolactinaemia also causes lower oestrogen and testosterone levels, causing ( osteoporosis, osteoarthritis, coeliac disease, crohn's disease ).

Explicação

Questão 28 de 34

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Metabolic syndrome is a known complication of atypical antipsychotics such as olanzapine that antagonise serotonin receptors.

Metabolic syndrome can only be diagnosed when at least 3 of which 5 symptoms are present in a patient?

Selecione uma ou mais das seguintes:

  • Central Obesity

  • Hypertension

  • Hyperglycaemia

  • High Serum Triglycerides

  • Low Serum HDL (cholesterol)

  • Low Serum LDL (cholesterol)

  • Hypoglycaemia

  • Hypotension

  • Hypothyroidism

  • Low Serum Calcium

Explicação

Questão 29 de 34

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Brian finds that the olanzapine helps him to sleep much better at night. Which neurotransmitter is primarily involved in this effect?

Selecione uma das seguintes:

  • Serotonin

  • Acetylcholine

  • Dopamine

  • Noradrenaline

  • Histamine

Explicação

Questão 30 de 34

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After taking Haloperidol, Brian develops a tremor and muscular stiffness. Which neuroreceptors are primarily involved in this effect?

Selecione uma das seguintes:

  • Serotonin

  • Acetylcholine

  • Dopamine

  • Noradrenaline

  • Histamine

Explicação

Questão 31 de 34

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Which antipsychotic is least likely to cause a recurrence of his parkinsonism?

Selecione uma das seguintes:

  • Risperidone

  • Olanzapine

  • Chlorpromazine

  • Quetiapine

  • Zuclopentixol

Explicação

Questão 32 de 34

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Haloperidol antagonises dopamine receptors in the pituitary gland. Which side effect is caused by this?

Selecione uma das seguintes:

  • Akathisia

  • Sexual Dysfunction

  • Acromegaly

  • Apathy

  • Sedation

Explicação

Questão 33 de 34

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After two failed trials of antipsychotics, which specific antipsychotic is usually given, under close observation?
( Clozapine, Mirtazapine, Cariprazine, Asenapine, Risperidone )

Explicação

Questão 34 de 34

1

Preencha o espaço em branco para completar o texto.

Patients taking Clozapine have their blood checked very often (once a week for first 6 months) as these patients are liable to developing , which could kill them.

Explicação