How caspases lead to cell death:

Active caspase 9, cleaves and activates effector caspase 3
Effector caspase targets and cleaves upto 40 genes, including the inhibitor of caspase activated DNase (ICAD)
CAD DNase now active, targets and fragments the DNA in the cell- doesnt discriminate between your DNA and viral DNA
Combined mitochondrial and DNA damage -> cell shrinkage and 'blebbing'= apoptotic bodies
- Encapsulation into apoptotic bodies is CRUCIAL to self-contain own and virus molecules

Phosphatidylserine relocates from intraceullular surface to extracellular PM of apoptotic body
Macrophages receptor recognises phosphatidylserine and engulf body- phagocytosis
Rapid removal of apoptotic bodies to prevent tissue autoimmunity , would get high levels of inflammation

	Criado por Chloe Cavarretta mais de 7 anos atrás

Immunology L17

8. Specialised Cells: CD8+ T Cells