Esther  Yook
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assessment 1.2

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Esther  Yook
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Assessment 1.2 Turning point

Questão 1 de 49

1

Which of the following statements is not true regarding the need for a dosage form:

Selecione uma das seguintes:

  • To protect the drug substance from the destructive influences of atmospheric oxygen or humidity

  • To conceal the bitter, salty, or offensive taste or odor of a drug substance.

  • To avoid drug-drug interactions thus providing greater clinical efficacy.

  • To provide for a safe and convenient delivery of accurate dosage

Explicação

Questão 2 de 49

1

Which of the following is not true for different crystal polymorphs

Selecione uma das seguintes:

  • May have different solubility

  • May have different dissolution rate

  • May have different chemical structure

  • May have different melting point

  • May have different physical and chemical stability

Explicação

Questão 3 de 49

1

Biopharmaceutics Classification System is used to classify drugs based on

Selecione uma das seguintes:

  • Melting point and pH

  • Aqueous solubility and bioavailability

  • Aqueous solubility and dissolution rate

  • Intestinal permeability and particle size

  • Dissolution rate and Intestinal permeability

  • Dissolution rate, aqueous solubility and intestinal permeability

Explicação

Questão 4 de 49

1

When being incorporated into ointment bases, fine powders such as calamine and zinc oxide are often wetted and smoothed with mineral oil. What name is given to this process

Selecione uma das seguintes:

  • Attrition

  • Levigation

  • Milling (pulverizing /grinding)

  • Pulverization by intervention

  • trituration

Explicação

Questão 5 de 49

1

Which factor does not affect the rate and extent of absorption from immediate release solid dosage froms

Selecione uma das seguintes:

  • Solubility

  • Dissolution

  • Appearance

  • Permeability

  • Particle size

Explicação

Questão 6 de 49

1

Which of the following is NOT a reason for the extemporaneous preparation of a dosage form

Selecione uma das seguintes:

  • Shortage of a marketed dosage form

  • Need a liquid dosage form for treating a pediatric patient

  • Medication is not commercially available

  • Geriatric patient is able to swallow solid oral dosage form

  • Patient may be allergic to preservative or dyes contained in the drug product

Explicação

Questão 7 de 49

1

Which of the following is used in tablet formulations to reduce friction during tablet compression

Selecione uma das seguintes:

  • Talc powder (Glidant)

  • Lactose (Diluents or Fillers)

  • Gum Acacia (Binders)

  • Magnesium stearate

  • Starch (Disintegrant)

  • Sodium carboxymethyl cellulose (Coatings)

Explicação

Questão 8 de 49

1

Before placing a patient onto IV fat emulsions, the pharmacist should confirm that the patient does not have:

Selecione uma das seguintes:

  • Egg allergies

  • Sensitivities to bisulfate

  • Milk intolerance

  • Lactose intolerance

  • Sensitivities to tartrazine

Explicação

Questão 9 de 49

1

Based on the pH partition theory, weakly acidic drugs are most likely to be absorbed from the stomach because:

Selecione uma das seguintes:

  • The drugs will exist primarily in the unionized, more lipid-soluble form

  • The drugs will exist primarily in the ionized, more water soluble form

  • Weak acids are more soluble in acid media

  • The ionic form of the drug facilitates dissolution

  • Weak acids will further lower the pH

Explicação

Questão 10 de 49

1

The passage of drug molecules from a region of high drug concentration to a region of low drug concentration is known as:

Selecione uma das seguintes:

  • Active transport

  • Bioavailability

  • Biopharmaceutics

  • Simple diffusion

  • Pinocytosis

Explicação

Questão 11 de 49

1

A prime consideration in biopharmaceutics is a drug’s “biovavailability” which refers to the relative amount of drug that reaches the :

Selecione uma das seguintes:

  • small intestine

  • stomach

  • Systemic circulation

  • Liver

  • kidneys

Explicação

Questão 12 de 49

1

Which of the following is not true if a physician would like the patient to use a generic product equivalent to the brand-name product

Selecione uma das seguintes:

  • Both the generic and the brand-name drug products must be pharmaceutical equivalents

  • Both the generic and the brand-name drug products must have the same bioavailability

  • Both the generic and the brand-name drug products must have the same excipients

  • Both the generic and the brand-name drug products must have identical amounts of the API

Explicação

Questão 13 de 49

1

Dosage forms of nitroglycerin that are minimally affected by the First-Pass effect include:
I. Intravenous
II. Transdermal patches
III. Sublingual tablets

Selecione uma das seguintes:

  • I only

  • III only

  • I and II only

  • II and III only

  • I, II and III

Explicação

Questão 14 de 49

1

Which of the following is not an advantage of a tablet dosage form:

Selecione uma das seguintes:

  • Accurate dosage/minimum variability

  • Easiest/cheapest to package and ship

  • Swallowing

  • Patient acceptance

  • Convenience (light and compact)

  • Tamper resistant

Explicação

Questão 15 de 49

1

Which of the following IVIVC classes is the intestinal permeability the rate limiting step in systemic drug absorption?

Selecione uma das seguintes:

  • Class IV

  • Class II

  • Class III

  • Class I

Explicação

Questão 16 de 49

1

Which of the following is the primary purpose of orally disintegrating tablet:

Selecione uma das seguintes:

  • Avoid exposure of content to stomach acid

  • Avoid hepatic first-pass effect

  • Increase drug bioavailability

  • Increase ease of swallowing

Explicação

Questão 17 de 49

1

Which of the following organic esters is commonly used in enteric coating of solid dosage forms:

Selecione uma das seguintes:

  • Phthalate

  • Tannate

  • Succinate

  • Acrylate

  • Phosphate

Explicação

Questão 18 de 49

1

Which of the following tablet dosage forms avoids the hepatic first-pass effects?

Selecione uma das seguintes:

  • Enteric coating

  • Instantly disintegrating

  • Chewable

  • Sublingual

  • Film coated

Explicação

Questão 19 de 49

1

The partial or complete separation of the top or bottom crowns of a tablet from the main body of the tablet is known as:

Selecione uma das seguintes:

  • Lamination

  • Slugging

  • Capping

  • Mottling

  • Picking

Explicação

Questão 20 de 49

1

False statement regarding the function of excipients used in tablet manufacture

Selecione uma das seguintes:

  • Binders promote granulation during the wet granulation process

  • Glidants help promote the flow of the tablet granulation during manufacture

  • Lubricants help patient swallow the tablets

  • Disintegrants are added to tablet formulations to facilitate the disintegration when the tablet contacts water in the gastrointestinal tract.

Explicação

Questão 21 de 49

1

Which manufacturing variables would be likely to affect the dissolution of a prednisone tablet in the body?

Selecione uma das seguintes:

  • The amount and type of binder

  • The amount and type of disintegrant added

  • The force of compression used during tableting

  • All of the above

Explicação

Questão 22 de 49

1

If the preparation is compounded from USP/NF ingredients,

Selecione uma das seguintes:

  • a beyond-use date of 3 months is appropriate

  • a beyond-use date of 6 months is appropriate

  • a beyond-use date of 9 months is appropriate

  • a beyond-use date of 12 months is appropriate

Explicação

Questão 23 de 49

1

Inconsistent in-vitro dissolution test results for the same solid oral dosage form of the same drug and strength generally indicate differences in all of the following EXCEPT:

Selecione uma das seguintes:

  • Dose units containing the same amount of drug but from different manufacturing process by the same manufacturer

  • Dose units from different batches or lots by the same manufacturer

  • Dose units from different manufacturers

  • Dose units from the same batch or lot

Explicação

Questão 24 de 49

1

The United States Pharmacopeia (USP) content uniformity test for tablets is used to ensure which quality?

Selecione uma das seguintes:

  • Bioequivalence

  • Dissolution

  • Potency

  • Purity

  • Toxicity

Explicação

Questão 25 de 49

1

Which of the following is most likely to occur with high speed machines that produce ≥ 10,000 tablets per minute?

Selecione uma das seguintes:

  • Granulation underfilling

  • Excessive tablet hardness

  • Inconsistent tablet weights

  • Capping

Explicação

Questão 26 de 49

1

United Stated Pharmacopeia (USP) tests to ensure the quality of drug products in tablet form include all of the following EXCEPT:

Selecione uma das seguintes:

  • Disintegration

  • Dissolution

  • Hardness and friability

  • Content uniformity

  • Weight variation

Explicação

Questão 27 de 49

1

Which of the following is false regarding dusting powders

Selecione uma das seguintes:

  • Dusted on the skin , no systemic action

  • Must be homogenous, free from potential of causing local irritation

  • Should flow easily, spread uniformly, and cling to the skin upon application

  • Have a systemic action

  • Generally dispensed in sifter-top containers

Explicação

Questão 28 de 49

1

Which of the following drug substance property is important for capsule size selection

Selecione uma das seguintes:

  • Bulk density

  • Particle size

  • Drug substance solubility

  • Melting point

Explicação

Questão 29 de 49

1

Which of the following is not part of Capsule Quality Control program

Selecione uma das seguintes:

  • Drug Content

  • Fill Weight

  • Disintegration

  • Dissolution

  • Hardness

  • Stability

  • Moisture permeation test

Explicação

Questão 30 de 49

1

The community pharmacist intends to prepare a fine dusting powder by triturating the components of the formulation in a mortar with a pestle and subsequently passing the mixture through a:

Selecione uma das seguintes:

  • 80 mesh sieve

  • 60 mesh sieve

  • 20 mesh sieve

  • 8 mesh sieve

Explicação

Questão 31 de 49

1

Which of the following can be influenced by Particle Size:

Selecione uma das seguintes:

  • Dissolution rate

  • Suspendability of suspensions

  • Uniformity of mixtures in powder dosage forms to ensure dose to dose content uniformity

  • Penetrability of particles for inhalation (dry powder inhaler) for deposition deep in the respiratory tract.

  • Nongrittiness of solid particles for ointments, creams, gels

  • All of the above

Explicação

Questão 32 de 49

1

When of the following drug substances will soften or liquefy when grinded

Selecione uma das seguintes:

  • Lactose

  • Starch

  • Camphor

  • Magnesium stearate

  • Sodium carboxy methylcellulose

Explicação

Questão 33 de 49

1

Which of the following is NOT an accurate characteristic of the rectum?

Selecione uma das seguintes:

  • It is approximately 15 – 20 cm in length

  • When void of fecal matter it has a fluid content of 2-3 ml

  • It is non-motile in resting state

  • The mucosal lining contains Goblet cells which release collagen into the lumen

Explicação

Questão 34 de 49

1

Of the veins that drain the blood from the rectal area, which one(s) bypass the liver and deliver blood directly to the systemic circulation?

Selecione uma das seguintes:

  • The inferior and middle rectal veins

  • The inferior and superior rectal veins

  • The middle and superior rectal veins

  • The inferior, middle and superior rectal veins

Explicação

Questão 35 de 49

1

Which of the following is NOT an advantage of drug dosing via rectal route?

Selecione uma das seguintes:

  • It can be used for unconscious patients

  • Rapid and predictable absorption as compared to other regions of GI tract

  • Hepatic first-pass metabolism may be avoided partially or completely

  • Drugs are not exposed to GI membrane enzymatic activity

Explicação

Questão 36 de 49

1

The maximum amount of solid that can normally be incorporated into a suppository is ______ of the blank weight.

Selecione uma das seguintes:

  • 20%

  • 30%

  • 40%

  • 50%

Explicação

Questão 37 de 49

1

While preparing a cocoa butter suppository with other ingredients, the melting point is lowered below that of room temperature. To elevate the melting point of the mixture you will add (select all that apply):

Selecione uma das seguintes:

  • Chloral hydrate

  • Menthol

  • Camphor

  • Beeswax

Explicação

Questão 38 de 49

1

Above what molecular weight do PEG polymers change from liquid to solid ?

Selecione uma das seguintes:

  • 100

  • 500

  • 1000

  • 5000

Explicação

Questão 39 de 49

1

The density factors of four drugs for cocoa butter are given below. For which drug would the greatest weight be required in order to displace 1 g of cocoa butter from a formulation ?

Selecione uma das seguintes:

  • Aminophylline (1.1)

  • Bismuth subnitrate (6.0)

  • Menthol (0.7)

  • Iodoform (4.0)

Explicação

Questão 40 de 49

1

Pharmacist patient-counseling points for proper use of rectal suppositories includes all of the following EXCEPT:

Selecione uma das seguintes:

  • PEG suppositories should not be stored in polystyrene vials because they react with polystyrene.

  • Before insertion PEG suppositories should be moistened with water.

  • Cocoa butter suppositories should be frozen first and then immediately inserted.

  • Suppositories should be inserted in an adult up to the first knuckle depth (~1 inch).

Explicação

Questão 41 de 49

1

Compared to the oral route of administration, all of the following are advantages of the rectalroute of administration EXCEPT:

Selecione uma das seguintes:

  • An effective route for treating nausea and vomiting.

  • Drugs are activated by the pH in the rectum to increase absorption.

  • Useful for administering drugs that cause stomach irritation.

  • Avoids first-pass hepatic deactivation.

Explicação

Questão 42 de 49

1

When using cocoa butter suppositories, which of the following drugs will result in the slowest drug release?

Selecione uma das seguintes:

  • Ionized hydrophilic drug

  • Unionized hydrophilic drug

  • Unionized lipophilic drug

  • Salt form of the drug

Explicação

Questão 43 de 49

1

Which of the following is NOT a component of the Lacrimal Apparatus?

Selecione uma das seguintes:

  • Lacrimal gland

  • Lacrimal ducts

  • Lacrimal sac

  • Lacrimal muscle

Explicação

Questão 44 de 49

1

Which layer(s) of the cornea offers the greatest barrier(s) to absorption into the eye for hydrophilic drugs?

Selecione uma das seguintes:

  • Epithelial layer

  • Stroma

  • Endothelial layer

  • 2 and 3 only

Explicação

Questão 45 de 49

1

To prevent possible corneal damage, ophthalmic formulations should be buffered in the pH range of:

Selecione uma das seguintes:

  • 3.5 to 11.5

  • 4.5 to 10.5

  • 5.5 to 9.5

  • 6.5 to 8.5

Explicação

Questão 46 de 49

1

Which of the following is NOT an antioxidant that has been found appropriate for use in ophthalmic formulations?

Selecione uma das seguintes:

  • Ethylenediaminetetra-acetic acid

  • Sodium Bisulfite

  • Thimerosal

  • Sodium metabisulfite

Explicação

Questão 47 de 49

1

pH buffers for ophthalmic solutions are designed and intended to provide all of the following EXCEPT:

Selecione uma das seguintes:

  • Patient comfort

  • Decreasing systemic absorption

  • Increasing drug stability

  • Increasing drug solubility

Explicação

Questão 48 de 49

1

The respiratory region of the nasal cavity is believed to be most suitable for drug delivery because:

Selecione uma das seguintes:

  • It is poorly supplied with blood vessels

  • It has a relatively large surface area

  • It contains stratified keratinized epithelial cells

  • It directly drains into the lungs

Explicação

Questão 49 de 49

1

All of the following statements about nasal drug delivery are true EXCEPT:

Selecione uma das seguintes:

  • Nasal bioavailability of a drug is typically lower than intravenous bioavailability

  • Nasally administered anesthetic agents can get absorbed by the olfactory region

  • Nasally absorbed drugs can bypass extensive hepatic metabolism

  • Nasal congestion does not affect the bioavailability of the drug

Explicação