Heroin

Review

Supraspinal sites of action

Sites of action

Consequences of MR +

Therapeutic uses of opioids

Problems with opioids as analgesics

Amytryptyline

Gabapentine

Carbamazepine

Naloxone

Tramadol

Pentacozine

Codeine

K (KOPr)

Morphine

Miosis

Nausea

Respiratory depression

Euphoria and drowsiness

Psychological dependence

Physical dependence

Which G proteins are opiod receptors coupled to?

Physical dependence

Analgesia

M (MOPr)

d (DOPr)