EXAMPLES

TRANSPORT CHARACTERISTICS

PHARMACEUTICAL PROBLEMS

PHARMOKINETIC PROBLEMS

PHARMACEUTICAL SOLUTION 1

PHARMACEUTICAL SOLUTION 2

PHARMACEUTICAL SOLUTION 3

SULPHANOMIDE AS A PRODRUG

GENERAL SYNTHESIS

SIMILARITIES WITH PABA

ROLE OF DIHYDROFOLATE REDUCTASE
DHF --> THF

BIOSYNTHESIS OF FOLATES

INHIBITION OF DHF PATHWAY 1

INHIBITION OF DHF PATHWAY 2