Angina Pharmacotherapy

Descrição

Quiz sobre Angina Pharmacotherapy, criado por Melanie Grynsztejn em 05-12-2017.
Melanie Grynsztejn
Quiz por Melanie Grynsztejn, atualizado more than 1 year ago
Melanie Grynsztejn
Criado por Melanie Grynsztejn mais de 6 anos atrás
20
1

Resumo de Recurso

Questão 1

Questão
Which beta blockers block both beta & alpha receptors?
Responda
  • Labetol
  • Carvedilol
  • Propanolol
  • Metroprolol

Questão 2

Questão
Beta‐1, found primarily in [blank_start]heart muscle[blank_end], results in increased heart rate, contractility, and atrioventricular (AV) conduction
Responda
  • heart muscle
  • bronchial & peripheral smooth muscle
  • adipose

Questão 3

Questão
Beta‐2, found in [blank_start]bronchial and peripheral vascular[blank_end] smooth muscle; results in vasodilatation and bronchodilation.
Responda
  • bronchial and peripheral vascular
  • heart muscle
  • adipose

Questão 4

Questão
Beta‐3, found in [blank_start]adipose tissue and the heart;[blank_end] may reduce cardiac contractility.
Responda
  • adipose tissue and the heart;
  • heart muscle
  • bronchial and peripheral vascular smooth

Questão 5

Questão
Beta blockers MOA:
Responda
  • Competitively inhibiting catecholamines from binding to these receptors.
  • Dilate veins, arteries, and coronary arteries by relaxing vascular smooth muscle
  • Act on vascular smooth muscle to reduce contraction of the arteries and cause vasodilation

Questão 6

Questão
Which of the following Beta Blockers are eliminated by hepatic metabolism and are lipid soluble
Responda
  • Propranolol
  • Metoprolol
  • Atenolol
  • Sotalol

Questão 7

Questão
Why is important to know which BB are eliminated by hepatic metabolism and more lipid soluble?
Responda
  • Enter CNS in high concentrations, possibly resulting in an increased incidence of CNS side effects
  • Are eliminated and do not as readily enter the CNS so can be prescribed more readily
  • Can cause hepatic damage if prescribed in too high a dosage

Questão 8

Questão
Which of the following beta blockers are excreted unchanged by the kidney?
Responda
  • Atenolol
  • Sotalol
  • Propranolol
  • Metoprolol

Questão 9

Questão
Metoprolol tartrate is [blank_start]shorter‐acting[blank_end] and dose [blank_start]*twice*[blank_end] daily and Metoprolol succinate [blank_start]longer‐ acting[blank_end] and dosed [blank_start]*once*[blank_end] daily
Responda
  • shorter‐acting
  • longer-acting
  • *twice*
  • *once*
  • longer‐ acting
  • shorter-acting
  • *once*
  • *twice*

Questão 10

Questão
Atenolol and sotalol are more water soluble and are eliminated unchanged by the kidney. What is the effect of this on plasma half-lives & bioavailability?
Responda
  • Longer plasma half-life
  • Shorter plasma half-life
  • Greater bioavailability
  • Lesser bioavailability

Questão 11

Questão
True or False: BB are first-line therapy to reduce angina episodes & increase exercise tolerance
Responda
  • True
  • False

Questão 12

Questão
BB & CCB are antianginal drugs proven to prevent reinfarction and improve survival in patients who have sustained a MI
Responda
  • True
  • False

Questão 13

Questão
BB should NOT be used in which type of angina patient
Responda
  • Stable
  • Unstable
  • Vasospastic (Prinzmetal)

Questão 14

Questão
It is important to [blank_start]taper[blank_end] BB when discontinuing BB therapy
Responda
  • taper

Questão 15

Questão
What are some potential Adverse Effects of Beta Blockers
Responda
  • Decreased heart rate, contractility & AV node conduction
  • Increased heart rate, contractility & AV node conduction
  • Bronchoconstriction
  • Bronchodilation
  • Nightmares, Insomnia, hallucinations
  • Depression
  • Weight loss
  • Weight gain
  • Erectile dysfunction

Questão 16

Questão
T or F CCB are less effective than BB when treating stable angina
Responda
  • True
  • False

Questão 17

Questão
When are CCB used to treat stable angina?
Responda
  • When BB is not successful
  • When BB is contraindicated
  • When BB are causing SE
  • Are never combined with BB

Questão 18

Questão
What is the caution for using both non‐dihydropyridine and BB?
Responda
  • Additive bradycardia
  • Orthostatic hypotension
  • Weakness
  • N/V/D

Questão 19

Questão
CCB improve anginal symptoms by causing coronary and [blank_start]peripheral[blank_end] vasodilatation and [blank_start]reducing[blank_end] contractility
Responda
  • peripheral
  • central
  • reducing
  • increasing

Questão 20

Questão
Select the non-dihydropyridine CCB:
Responda
  • Diltiazem
  • Verapamil
  • Amlodipine
  • Felodipine
  • Nifedipine

Questão 21

Questão
Which types of CCB are preferred for angina
Responda
  • Long-acting non-dihydropyridine CCB - Verapamil & Diltiazem
  • Second generation CCB - Amlodipine or Felodipine
  • 1st generation CCB - Nifidepine

Questão 22

Questão
What is the most concerning adverse effect of dihyrdropyridine (amlodipine, felodipine, nifedipine
Responda
  • Peripheral edema
  • Lightheadedness
  • Flushing

Questão 23

Questão
What are potential adverse effects of Dihydropyridines
Responda
  • Constipation
  • Bradycardia
  • Peripheral edema
  • Lightheadness
  • Flushing
  • Headache

Questão 24

Questão
What are potential adverse effects of non-dihydropyridines
Responda
  • Bradycardia
  • Constipation
  • Peripheral edema
  • Headache
  • Lightheadedness
  • Flushing

Questão 25

Questão
What are a prescribers options if a patient gets peripheral edema on a dihydropyridines?
Responda
  • Reduce dose
  • Add an angiotensin‐converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB)
  • Switch to a non‐dihydropyridine agent
  • Add a metered dose spray nitrate

Questão 26

Questão
MOA for nitrate used for stable angina is
Responda
  • Dilate veins, arteries, and coronary arteries by relaxing vascular smooth muscle.
  • Competitively inhibiting catecholamines from binding to these receptors.
  • Act on vascular smooth muscle reducing contraction of the arteries and causing vasodilation

Questão 27

Questão
Select the cardioselective beta blockers
Responda
  • Atenolol
  • Metoprolol
  • Propranolol

Questão 28

Questão
Select the non-cardioselective beta blockers
Responda
  • Meoprolol
  • Atenolol
  • Propranolol

Questão 29

Questão
Nitrates are used as
Responda
  • First‐line therapy for the treatment of acute anginal
  • Prophylactically for activities known to elicit angina
  • Ongoing management of stable angina

Questão 30

Questão
Usually in the form of a sublingual preparation, nitrates onset of action is within [blank_start]2‐5 minutes[blank_end] and duration of action [blank_start]15‐30 minutes[blank_end]
Responda
  • 2‐5 minutes
  • 5 - 10 minutes
  • 1 - 2 minutes
  • 15 ‐ 30 minutes
  • 5 - 10 minutes
  • 10 - 20 minutes
  • 15 - 20 minutes

Questão 31

Questão
Select the potential adverse effects of nitrates
Responda
  • Hypotension
  • Flushing
  • Bradycardia
  • Headache
  • N/V/D
  • LIghtheadedness

Questão 32

Questão
American College of Cardiology/American Heart Association (ACC/AHA) guidelines for calling the emergency services are
Responda
  • Contact EMS if chest pain or discomfort is unimproved or worsening 5 minutes after *one* nitroglycerin dose has been taken sublingually
  • Take one nitroglycerin dose sublingually every 5 minutes for up to *3 doses* before calling for emergency medical services evaluation.

Questão 33

Questão
Nitroglycerin tablets are both [blank_start]heat[blank_end] and [blank_start]light[blank_end] sensitive
Responda
  • heat
  • light

Questão 34

Questão
Nitroglycerin tablets should be stored in a tightly capped dark bottle in the refrigerator with only a small supply being carried by the patient and discarded after 12 months
Responda
  • True
  • False

Questão 35

Questão
The following are longer-acting nitrate therapies
Responda
  • Nitroglycerin table
  • Isosorbide dinitrate
  • Isosorbide mononitrate
  • Transdermal nitroglycerin patch

Questão 36

Questão
How can a patient address the issue of nitrate tolerance with long-term therapies like the transdermal nitroglycerin patch?
Responda
  • Nitrate‐free interval (at least approx 8‐10 hours)
  • Use patch on different sites on the body
  • Increase dosage of transdermal patch
  • Switch to short-term nitroglycerin tablet

Questão 37

Questão
What is a REALLY IMPORTANT nitrate contraindication drug
Responda
  • Warfarin (Coumadin)
  • Erectile dysfunction drugs, PDE-5, Sildenafil, Vardenafil or Tadalafil within 24 hours
  • Second generation dihydropyridine CCB drugs Amlodipine and Felodipine
  • Cardioselective BB drugs Atenolol and Metoprolol

Questão 38

Questão
Ranolazine is a new drug for stable angina that is recommended for patients that have failed all other antianginal therpies. However, it is contraindicated for the following patients
Responda
  • Pre-existing QT interval
  • Hepatic disease
  • Renal disease
  • Tachycardia

Questão 39

Questão
The following are angina PREVENTIVE therapies
Responda
  • ASA
  • Clopidogrel (Plavix) if allergic to aspirin
  • Verapamil if allergic to aspirin
  • Propranolol if allergic to aspiring

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