PHSI3011 08-1 Hormonal control of bone (PTH and sex steroids)

Michael Jardine
Quiz by , created about 2 years ago

PHSI3011 08-1 Hormonal control of bone (PTH and sex steroids)

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Michael Jardine
Created by Michael Jardine about 2 years ago
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Question 1

Question
[blank_start]__________[blank_end] serum Calcium – sensed by Calcium-sensing Receptor (CaR) in the [blank_start]__________[blank_end] triggers release of PTH.
Answer
  • Decreased
  • Increased
  • ParaThyroid Gland
  • Hypothalamus
  • Thyroid Gland

Question 2

Question
In response to decreased serum Calcium, PTH is released and goes to which of the following?
Answer
  • Kidney
  • Bone
  • Gut
  • Muscle
  • Liver

Question 3

Question
In the kidney, what PTH has 3 effects. These are: a: [blank_start]_____[blank_end] 1,25 (OH)2 D; b: [blank_start]_____[blank_end] Ca reabsorption; c: [blank_start]_____[blank_end] PO4 reabsorption;
Answer
  • Increase
  • Decrease
  • Increase
  • Decrease
  • Increase
  • Decrease

Question 4

Question
In the bone, PTH has 2 effects. These are: a: ↑ [blank_start]__________[blank_end]; b: ↑ Bone [blank_start]__________[blank_end] (releasing Ca).
Answer
  • Osteoclasts
  • Osteoblasts
  • Osteocytes
  • Lining Cells
  • Resorption
  • Formation

Question 5

Question
PTH-1 is a class-B GPCR. Yeah?
Answer
  • Yeah
  • Nah

Question 6

Question
The primary effect of Hyperparathyroidism is:
Answer
  • Increase blood Ca
  • Decrease blood Ca
  • Increase kidney Ca
  • Decrease kidney Ca

Question 7

Question
PROLONGED increase of PTH results in which of the following:
Answer
  • Increased osteoclasts
  • Decreased osteoclasts
  • Increased osteocytes
  • Decreased osteocytes
  • Increased bone resorption
  • Increased bone formation
  • Bone loss
  • Bone gain

Question 8

Question
The main effect of INTERMITTENT PTH is:
Answer
  • Increased osteoblast numbers
  • Increased osteoclast numbers
  • Decreased osteoblast numbers
  • Decreased osteoclast numbers

Question 9

Question
True or false: Intermittent PTH has little effect on osteoclasts, although they are necessary for its action.
Answer
  • True
  • False

Question 10

Question
Sclerostin is a [blank_start]__________[blank_end] regulator of bone formation.
Answer
  • Negative
  • Positive

Question 11

Question
Mutations that inactivate Sclerostin cause [blank_start]__________[blank_end] bone mass.
Answer
  • Increased
  • Decreased

Question 12

Question
Sclerostin is produced by which of the following:
Answer
  • Osteocytes
  • Osteoclasts
  • Osteoblasts
  • Lining Cells
  • PTH

Question 13

Question
Intermittent PTH [blank_start]__________[blank_end] sclerostin. Sclerostin [blank_start]__________[blank_end] Wnt signaling. Therefore Intermittent PTH has a [blank_start]__________[blank_end] effect on Wnt signalling and results in [blank_start]__________[blank_end] bone formation (and [blank_start]__________[blank_end] bone resorption).
Answer
  • Decreases
  • Increases
  • Inhibits
  • Stimulates
  • Positive
  • Negative
  • Increased
  • Decreased
  • Decreased
  • Increased