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Previous year Quizz 5

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Quiz on Previous year Quizz 5, created by Alba Del Rio Serrato on 03/12/2017.
Alba Del Rio Serrato
Quiz by Alba Del Rio Serrato, updated more than 1 year ago
Alba Del Rio Serrato
Created by Alba Del Rio Serrato over 6 years ago
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Resource summary

Question 1

Question
Which of the following answers is correct?
Answer
  • The NOAEL is defined as the highest dose at which no clinical and/or biological relevant adverse effect is observed in preclinical toxicology studies
  • The NOAEL is defined as the lowest dose at which at least one clinical and/or biological relevant adverse effect is observed in preclinical toxicology studies

Question 2

Question
The following are true about the early stages of schizophrenia: (more than one answer might be correct)
Answer
  • Attention deficits may be present
  • Motor dysfunction is an early warning sign.
  • Medical interventions prior to the first psychotic symptoms may be more effective
  • Brain structure that is clearly different from healthy individuals
  • Mild or moderate disturbance in language.

Question 3

Question
Schizophrenia is a genetic disorder,
Answer
  • but it is not heritable
  • and its heritability is around 80%.
  • and environmental factors are not important.
  • and its heritability is around 10%.
  • but genetics factors are not associated with schizophrenia symptoms

Question 4

Question
What types of bias affect the "internal validity" of a study? (several answers are correct)
Answer
  • selection bias (creating groups with different confounders; solved by randomization)
  • performance bias and detection bias (investigators respectively treating or assessing more positively those subjects on the treatment arm; controlled by blinding interventions and outcome assessments)
  • attrition bias (dropout of subjects with a negative outcome not included in the final result)

Question 5

Question
Which brain function is dominated most by one hemisphere?
Answer
  • Hearing
  • Smelling
  • Language
  • Memory
  • Vision

Question 6

Question
Which of these anatomic structures is not part of the basal ganglia?
Answer
  • Corpus striatum
  • Red nucleus
  • Subthalamic nucleus
  • Caudate nucleus

Question 7

Question
A meta-analysis is a study that
Answer
  • retrospectively combines all trials performed by one group
  • eliminates the bias introduced by studies of low quality
  • can only be performed when more than 10 trials have been performed
  • is a prospective trial of study quality
  • none of the above

Question 8

Question
Which study(ies) belong(s) to Phase I? (more than one answer might be correct
Answer
  • Bioequivalence
  • First in Human
  • Pharmacokinetics in renal impairment
  • Proof of concept
  • Pharmacokinetic drug interaction

Question 9

Question
What has the neurotransmitter dopamine been shown to encode?
Answer
  • stop signals
  • reward signals
  • fear signals
  • motor signals

Question 10

Question
Which answer is incorrect? Risk factors for schizophrenia include:
Answer
  • Weight gain
  • Influenza infection during pregnancy
  • Toxoplasmosis gondii
  • Age of father at conception
  • High expressed emotions families

Question 11

Question
What is the main advantage of bipolar electrophysiological recordings, compared to a common reference?
Answer
  • better spectral resolution
  • better time resolution
  • better spatial resolution
  • higher amplification

Question 12

Question
Which of the following statements is correct?
Answer
  • A SUE is always related to the administration of the test substance
  • A SUSAR can be a serious or a non-serious adverse reaction
  • A SUSAR should be reported to Ethic Committee and Health Authorities

Question 13

Question
The attrition (=failure) rate from first in man to registration of a drug in medicine is typically ...
Answer
  • 50%
  • 90%
  • 20 %
  • 30%
  • E. 99%

Question 14

Question
What are the legal preconditions for the conduct of a clinical study? (more than one answer is correct)
Answer
  • IRB approval
  • Insurance Certificate
  • Data protection approval
  • Youth welfare office approval
  • Study bank account

Question 15

Question
Which of the following statements is correct?
Answer
  • The first dose in humans is equivalent to NOAEL
  • The first dose in humans is a fraction of NOAEL
  • The first dose in humans is higher than NOAEL

Question 16

Question
Ownership of intellectual property in academic research in Germany and the US is held by
Answer
  • the inventor(s)
  • the funding agency
  • the University
  • Researcher(s) who are not employed by the University but inventor(s)
  • the University Researcher(s) who are not employed by the University but inventor(s)

Question 17

Question
Which of the following statements is true regarding the striatum? (more than one answer is correct)
Answer
  • receives inhibitory input from the cortex
  • consists of the lenticular nucleus and the putamen
  • receives dopaminergic input from the substantia nigra pars compacta
  • contains cells that use acetylcholine as their transmitter
  • all of the above statements are true

Question 18

Question
Which other description of the clinical symptom chorea is correct?
Answer
  • Babinski sign
  • akinesia
  • rigidity
  • uncontrollable involuntary movement
  • spasticity

Question 19

Question
The primary outcome of a First-in-Human study is always:
Answer
  • Safety and tolerability
  • Feasibility
  • Pharmacodynamics
  • Therapeutic effect
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