Quiz
Neuropathology II - Demyelination & Dementia
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Questions in this quiz (40)
1What is the most common demyelinating disease?
[blank_start]Multiple Sclerosis[blank_end]- AMultiple Sclerosis
2Multiple sclerosis is more prevalent in women than men
- ATrue
- BFalse
3The peak incidence for diagnosis of Multiple Sclerosis is ...
- A13-18 years old
- B20-30 years old
- C40-50 years old
- D>50 years old
4The demyelination associated with MS is best seen on which type of brain scan?
- AT1 MRI Brain Scan
- BT2 MRI Brain Scan
5Demyelinating plaques in MS typically affect the ...
- Awhite matter of the brain
- Bgrey matter of the brain
- Cmeningeal-cerebral border
6What type of tumour tend to typically arise at the cerebellopontine angle?
[blank_start]Vestibular schwannoma[blank_end]- AVestibular schwannoma
7One way of diagnosing MS is via lumbar puncture looking for oligoclonal [blank_start]IgG[blank_end] bands in the CSF
- AIgG
- BIgA
- CIgE
8Dementia occasionally occurs as part of the natural ageing process and is not considered pathological.
- ATrue
- BFalse
9What is the most common subtype of dementia?
- AAlzheimer's Disease
- BVascular Dementia
- CDementia with Lewy Bodies
- DFrontotemporal Dementia
10Alzheimer's Disease affects 2x more women than men
- ATrue
- BFalse
11Alzheimer's Disease has a higher incidence in Trisomy 21 (Down's Syndrome) patients
- ATrue
- BFalse
12One of the mot prominent macroscopic features of Alzheimer's Disease is the cortical atrophy. Which 3 lobes tend to be most heavily affected by this?
- AFrontal lobe
- BTemporal lobe
- CParietal lobe
- DOccipital lobe
- ELacunar lobe
13Looking at the slices shown here, which of the brains is most likely to have had Alzheimer's Disease?
- A1
- B2
- C3
14Neurofibrillary tangles are typical of Alzheimer's Disease. They typically occur in the [blank_start]temporal[blank_end] lobe and [blank_start]hippocampus[blank_end] (memory centre) and are associated with the [blank_start]Tau[blank_end] protein.
- ATau
- Btemporal
- Chippocampus
15Alzheimer's Disease patients also show Neuritic Plaques in the brains. These are plaques surrounding astrocytes and microglia, composed of what type of amyloid?
- AAmyloid beta peptide (Aβ)
- BSerum amyloid A
- CAmyloid delta peptide (Aδ)
- DAmyloid gamma peptide (Aγ)
16The reason Alzheimer's is more prevalent in Down's Syndrome is due to the fact that the protein cleaved to form amyloid beta peptide is on the 21st chromosome. Having three of these makes accumulation of beta amyloid more probable.
- ATrue
- BFalse
17Amyloid beta protein is formed by the cleavage of ...
- AAmyloid precursor protein
- BAmyloid progenitor protein
- CAmyloid forming protein
- DAmyloid catalysing protein
18In terms of histology, which stain is used to best identify beta amyloid peptides, thus aiding a diagnosis of Alzheimer's Disease?
- ACongo Red
- BHematoxylin
- CCarmine
- DMethyl Blue
- EMethyl Green
- FToluidine Blue
- GOrange G
- HAniline Blue
19Which 3 of the following symptoms are important in differentiating Dementia with Lewy Bodies (DLB) from Alzheimer's Disease?
- ADifficulty walking and a decrease in balance. Typical Parkinsonism symptoms
- BVisual hallucinations
- CHeadache
- DFluctuations in memory loss
- EMoodswings
20Parkinsonism usually occurs due to damage to which part of the basal ganglia?
[blank_start]Substantia Nigra[blank_end]- ASubstantia Nigra
21Which type of dementia is also due to degeneration of the substantia nigra?
- ADementia with Lewy Bodies
- BAlzheimer's Disease
- CHuntington's Disease
- DFrontotemporal Dementia
- EVascular Dementia
22Which two of the following proteins tend to accumulate in Dementia with Lewy Bodies?
- A∝-Synuclein
- BUbiquitin
- CTau
- DAmyloid Beta
- EApolipoprotein
- FITM2B
- GGlial Fibrillary Acidic Protein
23The gene known to cause the autosomal dominant Huntington's disease is called [blank_start]Huntingtin[blank_end]
- AHuntingtin
24Huntington's disease typically causes the greatest extent of atrophy in which of the following basal ganglia structures?
- ACaudate Nucleus
- BPutamen
- CGlobus Pallidus
25Pick's Disease is also known as ...
- AFrontotemporal Dementia
- BVascular Dementia
- CCreutzfeldt-Jakob Dementia
26Which of the 3 following symptoms are most common in Fronto-Temporal Dementia
- AFluctuating memory loss
- BParkinsonism-like symptoms (gait problems, loss of balance, etc)
- CPersonality and behavioural change
- DSpeech and communication problems
- EChanges in eating habits
- FSensory weakness in face and arms
- GSensory weakness in legs
27The inability to recognise objects seen as part of Alzheimer's Disease is known as [blank_start]Agnosia[blank_end]
- AAgnosia
28Two or more of the following symptoms is diagnostic of which type of dementia?
Visual hallucinations
Fluctuating cognition (delirium-like)
REM sleep behaviour disorder
Parkinsonism (not more than 1 year prior to onset of dementia)
Positive DAT scan- ADementia with Lewy Bodies
- BVascular Dementia
- CFrontotemporal Dementia
- DAlzheimer's Dementia
29What is the first line scanning modality for someone suspected of dementia?
- ACT Scan
- BMRI Scan
- CSPECT
- DDAT Scan
30Which imaging modality is most useful for frontotemporal dementia?
- ACT Scan
- BMRI Scan
- CSPECT Scan
- DDAT Scan
31Which imaging modality is most useful for clarifying Parkinsons Plus Syndromes such as Dementia with Lewy Bodies?
- ACT Scan
- BMRI Scan
- CSPECT Scan
- DDAT Scan
32A 86 year old woman presents to her GP which her daughter, who complains that her mother has had progressive memory loss over the past 3 months. Her mother also complains that she has been seeing spiders crawling up the walls of her apartment and has recently developed a tremor in her hands.
What type of dementia is she likely to have?- ADementia with Lewy Bodies
- BFrontotemporal
- CAlzheimer's Disease
- DVascular Dementia
33What is the first line medical treatment for Alzheimer's Disease?
- ACholinesterase Inhibitors
- BAntipsychotics
- CAntidepressants
- DDopamine Receptor Inhibitors
- EGlutamatergic Inhibitors
34Which of the below mentioned drugs is an example of a Cholinesterase Inhibitor used to treat Alzheimer's Disease?
- ADonepezil
- BLoxapine
- CThiothixene
- DFluphenazine
- EMesopezil
35If an Alzheimer's/DLB patient fails on Anticholiniergics, or diagnosed with moderate/severe dementia, what drug should they be prescribed?
[blank_start]Memantine[blank_end]- AMemantine
36It is not mandatory to report a dementia diagnosis to the DVLA
- ATrue
- BFalse
37In terms of memory loss:
[blank_start]Anterograde Amnesia[blank_end] - difficulty in acquiring new material and remembering events since the onset of the illness or injury.
[blank_start]Retrograde Amnesia[blank_end] - difficulty in remembering information prior to the onset of the illness or injury- ARetrograde Amnesia
- BAnterograde Amnesia
38Creutzfeldt–Jakob disease is a fatal degenerative brain disorder. It causes memory loss, visual disturbances, blindness and is believed to be caused by the protein [blank_start]Prion[blank_end]
- APrion
- BTau
- CSynuclein
- DBeta amyloid
- EPresenilin 2
- FAmyloid Precursor Protein
39A 67 year old women on Ward 2 of Ninewells, admitted for a UTI, has a 3 day history of memory loss and fluctuating cognition. She is not orientated to time or place. It is likely she is suffering from [blank_start]Delirium[blank_end]
- ADelirium
40Visual hallucinations are common in [blank_start]Delirium[blank_end]
- ADelirium
- BDementia
- CDepression
Information
- Description
- Neuropathology II - Demyelination & Dementia given in Week 4 Includes Memory Loss lectures given during Week 4
- Author
- Matthew Coulson
- Language
- English
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- 62
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