General pathology

Nada Medhat
Quiz by Nada Medhat, updated more than 1 year ago
Nada Medhat
Created by Nada Medhat almost 3 years ago
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Description

multiple choice question on general pathology for 3rd year medical students

Resource summary

Question 1

Question
A tumour has to grow larger than 1-2mm. What supportive mechanism will be required? Identify the correct statement.
Answer
  • Angiogenesis
  • Application of promotors
  • Application of initiators
  • Growth factors
  • Secondary mutations

Question 2

Question
Genes that promote autonomous cell growth in cancer cells are called as;
Answer
  • Anti-apoptotic genes
  • DNA repair genes
  • Oncogenes
  • Tumour suppressor genes
  • RNA repair genes

Question 3

Question
A patient of adenomacarcinoma of prostate is treated by the oncologist and is under regular follow-up. Which serum tumour marker will help in determining tumour recurrence
Answer
  • CA 125
  • CEA
  • PSA
  • Prolactin

Question 4

Question
Individuals who have hereditary predisposition to cancer, the detection of mutated alleles may allow the patient and physician to devise an aggressive screening program and consider the option of prophylactic surgery and counseling of relatives at risk. This is not seen in germ line mutation of:
Answer
  • APC
  • BRCA1
  • BRCA2
  • KRAS
  • none of the above

Question 5

Question
The incidence of carcinoma of cervix has fallen down in West because of the effective screening program for early detection of premalignant lesions. Select one diagnostic modality for screening of cervical cancer in your population
Answer
  • CT scan
  • Pap smear
  • PCR
  • Serum CA-125 levels
  • cervical x-ray

Question 6

Question
In evolution of colorectal cancers through adenoma-carcinoma sequence identify mutation of gene which is an early event.
Answer
  • APC
  • P53
  • KRAS
  • SMAD1
  • BRACA!

Question 7

Question
The earliest mechanism for increased vascular permeability in acute inflammatory response is:
Answer
  • Increased transcytosis
  • Direct endothelial cell damage
  • Leucocyte mediated endothelial injury
  • Cytoskeletal reorganization
  • Endothelial cell contraction

Question 8

Question
An athelete develops acute throat infection. In addition to local acute inflammatoryt changes he develops fever and malaise. These constitutional symptoms are mediated by
Answer
  • Histamine
  • IL-1 & TNF
  • C3a
  • Prostacyclin
  • Thromboxane A2

Question 9

Question
A 55-year-old woman has been treated in the hospital for pancreatitis for the past three weeks. She is examined one morning on rounds and found to have a swollen right leg. It is tender to palpation posteriorly but is not warm. This condition is most likely to be the result of which of the following vascular complications?
Answer
  • Venous thrombosis
  • Septic embolization
  • Congestive heart failure
  • Cellulitis
  • Infarction

Question 10

Question
Causes of localized Oedema include:
Answer
  • Loss of proteins through kidneys
  • Loss of proteins through gut
  • Obstruction of lymphatics
  • Congestive cardiac failure
  • none of the above

Question 11

Question
Type III hypersensitivity reaction develops when:
Answer
  • Antigens are trapped in macrophages and cannot be cleared
  • Antibody binds to either self antigen or foreign antigen on cells
  • An IgE antibody response is directed against harmless environmental antigens
  • Immune complexes are formed in large quantities and cannot be cleared
  • IgM is produced as a part of primary humoral response

Question 12

Question
After a minor trauma to the big toe, a child develops painful swelling over it which is red warm and tender. The swelling is fluctuant. The surgeons diagnose it to be an abscess which is
Answer
  • An area of chronic inflammation with granulomas in it
  • A localized collection of transudate
  • A localized collection of granulation tissue
  • An area of collagen deposition
  • A localized collection of pus

Question 13

Question
The difference between GHON COMPLEX and GHON LESION is
Answer
  • Primary lesion + Draining Lymph nodes in Ghon complex.
  • Reinfection or without involvement of draining lymph nodes in Ghon complex.
  • In Ghon lesions draining lymph nodes are involved.
  • In Ghon complex draining lymph nodes are not involved.
  • In Ghon lesion draining lymph nodes are involved.

Question 14

Question
A 40 years old male presents to his physician with maculopapular rashes on his palm and soles, low grade fever, malaise, anorexia, weight loss, headache and myalgias. Examination reveals generalized lymphadenopathy.On further questioning he gives a history of non tender ulcer in his groin regions 2 months prior to his present symptoms what is the most likely organism responsible:
Answer
  • Borellia recurrentis
  • leptospira interrogans
  • Borellia burgdoferri
  • HIV
  • treponema pallidum

Question 15

Question
A young man of 20 , got a lacerated wound on his left arm , stiched-1week later surures were remained-healing continued but the site became disfigured by prominent raised irregular nodular scar , in next 2 month which of the following best describes the process :
Answer
  • Organization
  • Dehiscence
  • Resolution
  • Keloid formation
  • Secondary union

Question 16

Question
the growth factor elaborated by macrophages , which recruits macrophages and fibroblasts to wound site and induces all steps in angiogenesis :
Answer
  • vascular endothelial growth factor
  • fibroblast growth factor
  • epithelial growth factor
  • platelet derived growth factor

Question 17

Question
the most characteristic features of granulation tissues is that :
Answer
  • growth of fibroblast and new capillaries
  • character of the exaudate
  • granular scar that results
  • presence of momocytes and fibroblasts

Question 18

Question
which of the following is a reversible changes :
Answer
  • pyknosis
  • karyolysis
  • swelling of endoplasmic reticulum
  • karyorrhexis

Question 19

Question
after initiation of an acute inflammatory process third in a sequence of changes in vascular flow is :
Answer
  • vasoconstriction
  • redness
  • leukocytic migrationn
  • vasodilatation

Question 20

Question
which of the following types of necrosis is most commonly associated with ischemic injury :
Answer
  • coagulative necrosis
  • liquifactive necrosis
  • caseous necrosis
  • fat necrosis
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