Pharmacology

Berfin Miiau
Quiz by Berfin Miiau, updated more than 1 year ago
Berfin Miiau
Created by Berfin Miiau over 2 years ago
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Description

Quiz on Pharmacology , created by Berfin Miiau on 12/24/2018.

Resource summary

Question 1

Question
the main routes of enteral administration of drugs are
Answer
  • oral
  • by injection
  • rectal
  • per mucosa

Question 2

Question
Advantages of the oral route of drug administration are
Answer
  • easily self-administered
  • toxicity and overdose may be overcome with antidotes
  • drugs avoid first-pass metabolism
  • drugs go directly into the systemic circulation

Question 3

Question
Advantages of the rectal route of drug administration are
Answer
  • suitable for vomiting patients
  • suitable for children
  • suitable for unconscious patients
  • a way to avoid first-pass metabolism

Question 4

Question
Disadvantages of iv drug administration are
Answer
  • a trained staff is required
  • risk of bacterial contamination at the site of injection
  • it is painful and stressful for the patient
  • drugs undergo first-pass metabolism in the liver

Question 5

Question
Point out the correct statements for iv drug administration
Answer
  • aqueous solutions can be administered iv
  • oil solutions can be administered iv
  • has the highest bioavailability
  • used for treatment of life-threatening conditions

Question 6

Question
The subject of pharmacokinetics is
Answer
  • drug absorption and distribution
  • drug biotransformation
  • drug elimination
  • drug biological activity

Question 7

Question
Point out the correct statements for passive diffusion
Answer
  • does not require energy
  • requires energy
  • involves a carrier
  • drugs move from high to lower concentration

Question 8

Question
The diffusion of lipid soluble drugs
Answer
  • depends on the charge of the drug molecule
  • does not depend on the charge of the drug molecule
  • is penetration through aqueous channels or pores
  • is penetration through the biological membranes

Question 9

Question
A drug-weak acid will be absorbed
Answer
  • in a medium with low pH
  • in a medium with high pH
  • in the stomach
  • in the intestine

Question 10

Question
A drug-weak base will be absorbed
Answer
  • in a medium with low pH
  • in a medium with high pH
  • in the stomach
  • in the intestine

Question 11

Question
Point out the correct statements for active drug transport
Answer
  • it is energy- dependent
  • it is not energy- dependent
  • requires carriers
  • does not require carriers

Question 12

Question
Point out the correct statement for drugs bound to plasma proteins
Answer
  • bound drugs are pharmacologically active
  • only the unbound drugs can act on target sites in the tissues
  • only the bound drugs are available to the process of elimination
  • drugs may displace each other from the binding proteins

Question 13

Question
Drug metabolism may
Answer
  • increase a drug's pharmacological activity
  • decrease a drug's pharmacological activity
  • change the pharmacological effects of a drug
  • change the toxicity of a drug

Question 14

Question
first phase liver metabolism reactions include
Answer
  • acetylation
  • conjugation
  • reduction
  • oxidation

Question 15

Question
Second phase liver metabolism reactions include
Answer
  • acetylation
  • conjugation
  • reduction
  • oxidation

Question 16

Question
Phase I of drug metabolism
Answer
  • may or may not involve cytochrome P450 system
  • phase I reactions convert lipophilic molecules to more polar molcecules
  • includes alcohol dehydrogenation, amine oxidation, hydrolysis
  • consists of conjugation reactions

Question 17

Question
Renal excretion of a drug will be reduced if
Answer
  • the drug is a weak acid and the urine is alkaline
  • the drug is a weak acid and the urine is acidic
  • the drug is a weak base and the urine is alkaline
  • the drug is a barbiturate and the urine is alkaline

Question 18

Question
Drug pharmacodynamics includes
Answer
  • drug effects
  • mechanisms of drug action
  • drug elimination
  • how the organism changes drugs

Question 19

Question
The changes that occur due to the interaction between drug molecules and organism structures are called
Answer
  • drug effect
  • drug action
  • adverse drug reaction
  • placebo effect

Question 20

Question
The organism response as a result of the changes that have occured due to its interaction with the drug is called
Answer
  • drug action
  • drug effect
  • adverse drug reaction
  • placebo effect

Question 21

Question
What is characteristic for a drug receptor
Answer
  • induces (generates) a change in organism functions
  • has selectivity
  • has sensitivity
  • has specifity

Question 22

Question
Agonists are ligands which
Answer
  • have affinity
  • block receptors
  • have intrinsic activity
  • bind to the receptor

Question 23

Question
Antagonists are ligands which
Answer
  • have strong affinity
  • have intrinsic activity
  • block the receptor
  • do not have intrinsic activity

Question 24

Question
Therapeutic margin is the
Answer
  • difference between maximal toxic and minimal therapeutic doses
  • ratio between minimal toxic and minimal therapeutic doses
  • difference between mean lethal and mean effective doses
  • ratio between lethal and mean effective doses

Question 25

Question
Drugs' therapeutic index is the
Answer
  • difference between minimal toxic and minimal therapeutic doses
  • ratio between minimal toxic and minimal therapeutic doses
  • difference between mean lethal and mean effective doses
  • ratio between mean lethal and mean effective doses

Question 26

Question
Types of drug interaction are
Answer
  • synergy
  • antagonism
  • synergy/ antagonism
  • chemical antagonism (formation of complexes)

Question 27

Question
Potentiation can be observed during the concomitant use of
Answer
  • Fentanyl and Droperidol
  • Heparin and Protamine
  • Amoxicillin and Clavulonic acid
  • Diazepam and Flumazenil

Question 28

Question
Full competitive antagonist of opioid receptors, administered in acute opioid intoxication is
Answer
  • Allylnormorphine
  • Methadone
  • Naloxone
  • Flumazenil

Question 29

Question
Chemical antagonism or complex formation can be observed in
Answer
  • Morphine and Naloxone
  • Diazepam and Flumazenil
  • Epinephrine and Histamine
  • Iron preparation and Deferroxamine

Question 30

Question
Which of the following are enzyme inducers
Answer
  • Phenytoin
  • Phenobarbital
  • Metamizol
  • Metronidazole

Question 31

Question
Multiple drug administration could lead to
Answer
  • drug tolerance
  • drug dependence
  • drug accumulation
  • allergic reactions

Question 32

Question
Drug addicition/ dependence involves
Answer
  • drug tolerance
  • physical dependence
  • psychological dependence
  • allergy

Question 33

Question
Antiseptics are used for
Answer
  • decontamination of laundry and sanitary facilities
  • decontamination of skin and mucous membranes
  • internal administration
  • treatment of fever

Question 34

Question
Disinfectants are used for decontamination of
Answer
  • urine, faeces and other
  • mouth
  • instruments
  • clothing and underwear

Question 35

Question
Antiseptics and disinfectants are
Answer
  • detergents
  • barbiturates
  • oxidizing agents and halogen derivatives
  • phenols
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