Introduction To Haemostasis

Matthew Coulson
Quiz by Matthew Coulson, updated 10 months ago
Matthew Coulson
Created by Matthew Coulson 11 months ago
2
1

Description

Medicine (Haematology - Week 2) Quiz on Introduction To Haemostasis , created by Matthew Coulson on 03/04/2019.

Resource summary

Question 1

Question
Primary Haemostasis = [blank_start]Formation of Platelet Plug[blank_end] Secondary Haemostasis = [blank_start]Formation of Fibrin Clot[blank_end]
Answer
  • Formation of Fibrin Clot
  • Formation of Platelet Plug

Question 2

Question
Platelets are formed on the surface of which type of cell? [blank_start]Megakaryocyte[blank_end]
Answer
  • Megakaryocyte

Question 3

Question
As a platelet has a lifespan of [blank_start]7-10 days[blank_end], a patient on e.g. aspirin should have this medication stopped this period of time before surgery to avoid any unnecessary bleeding.
Answer
  • 7-10 days
  • 10-14 days
  • 14-21 days

Question 4

Question
Platelets are formed on the surface of megakaryocytes which are found within the bone marrow
Answer
  • True
  • False

Question 5

Question
Von Willebrand Factor binds to Factor [blank_start]VIII[blank_end] in the circulation. Without WVF the aforementioned factor would be broken down in the blood.
Answer
  • VIII

Question 6

Question
Factor VIII is released from Von Willebrand Factor by action of [blank_start]Thrombin[blank_end] (Factor [blank_start]IIa[blank_end])
Answer
  • IIa
  • Thrombin

Question 7

Question
Von Willebrand factor also forms part of the platelet mesh that forms in response to bleeding, holding the platelets together.
Answer
  • True
  • False

Question 8

Question
Reduced number of platelets in the blood is known as [blank_start]thrombocytopenia[blank_end]
Answer
  • thrombocytopenia

Question 9

Question
The commonest inherited bleeding disorder is a deficiency of [blank_start]Von Willebrand Factor[blank_end]
Answer
  • Von Willebrand Factor

Question 10

Question
Which usually results in a more serious bleed?
Answer
  • Primary Haemostasis failure
  • Secondary Haemostasis failure

Question 11

Question
Failure of primary haemostasis typically causes which 3 of the following?
Answer
  • Epistaxis
  • Conjunctival bleeding
  • Menorrhagia
  • Ischaemic stroke
  • Coronary artery infarction

Question 12

Question
If you were concerned about the failure of primary haemostasis you would check the [blank_start]platelet[blank_end] count in the blood.
Answer
  • platelet

Question 13

Question
Coagulation Cascade (1): Tissue Factor binds with Factor [blank_start]VIIa[blank_end]
Answer
  • VIIa

Question 14

Question
Coagulation Cascade (2): TF-VIIa Complex activates Factor [blank_start]X[blank_end] to Factor [blank_start]Xa[blank_end]. In the meantime, TF-VIIa also activates Factor [blank_start]IX[blank_end] to Factor [blank_start]IXa[blank_end]. This Factor then binds with Factor [blank_start]VIIIa[blank_end] and this complex then also activates Factor [blank_start]X[blank_end] to Factor [blank_start]Xa[blank_end]
Answer
  • Xa
  • X
  • IX
  • IXa
  • VIIIa
  • X
  • Xa

Question 15

Question
Coagulation Cascade (3): Factor Xa then binds with Factor [blank_start]Va[blank_end] to form the enzyme [blank_start]prothrombinase[blank_end], which facilitates the conversion of [blank_start]Prothrombin[blank_end] (Factor [blank_start]II[blank_end]) to [blank_start]Thrombin[blank_end] (Factor [blank_start]IIa[blank_end])
Answer
  • Prothrombin
  • II
  • Thrombin
  • IIa
  • prothrombinase
  • Va

Question 16

Question
Coagulation Cascade (4): Thrombin (Factor IIa) then goes about activating Factor [blank_start]VIII[blank_end] to Factor [blank_start]VIIIa[blank_end], in turn releasing it from its binding to [blank_start]Von Willebrand Factor[blank_end], whilst also activating Factor [blank_start]V[blank_end] to Factor [blank_start]Va[blank_end]
Answer
  • V
  • Va
  • Von Willebrand Factor
  • VIIIa
  • VIII

Question 17

Question
Coagulation Cascade (5): The main function of Thrombin, however, is in the activation of [blank_start]Fibrinogen[blank_end] (Factor I) to [blank_start]Fibrin[blank_end] (Factor Ia).
Answer
  • Fibrin
  • Fibrinogen

Question 18

Question
Coagulation Cascade (6): Finally, soluble Fibrin produced by thrombin-mediated activation is organised into crosslinked Fibrin by action of Factor [blank_start]VIIIa[blank_end]
Answer
  • VIIIa

Question 19

Question
Fibrin is broken down into Fibrin Degradation Products (e.g. D-dimers) via which enzyme? [blank_start]Plasmin[blank_end]
Answer
  • Plasmin

Question 20

Question
Plasminogen --> Plasmin is mediated by which enzyme, which is thus used clinically as a thrombolytic agent? [blank_start]Tissue Plasminogen Activator[blank_end]
Answer
  • Tissue Plasminogen Activator

Question 21

Question
Screening tests for Fibrin Clot Formation: [blank_start]Prothrombin Time[blank_end]: Tests TF-VIIa complex activating factor X so that the Xa/Va complex (prothrombinase) can be produced. [blank_start]Activated Partial Thromboplastin Time[blank_end]: Tests VIIIa/IXa complex activating Factor X so that the Xa/Va complex (prothrombinase) can be produced.
Answer
  • Activated Partial Thromboplastin Time
  • Prothrombin Time

Question 22

Question
Anti-Thrombin III binds to ... thus inhibiting secondary haemostasis
Answer
  • Thrombin (Factor IIa) only
  • Thrombin (Factor IIa) & Prothrombinase (Xa/Va complex)
  • Prothrombinase (Xa/Va complex) only
  • TF-VIIa & VIIIa/IXa complexes only
  • Thrombin (Factor IIa), Prothrombinase (Xa/Va complex) & the TF-VIIa and VIIIa/IXa complexes

Question 23

Question
Thrombin can bind to an endothelial cell forming thrombomodulin, which in turn activates Protein [blank_start]C[blank_end] and Protein [blank_start]S[blank_end] (give in alphabetical order).
Answer
  • S
  • C

Question 24

Question
Proteins C & S affect which complexes?
Answer
  • Prothrombinase (Xa/Va complex) only
  • Prothrombinase (Xa/Va complex) & TF-VIIa complex
  • Prothrombinase (Xa/Va complex) & VIIIa/IXa complex

Question 25

Question
Deficiency of clotting factors is called [blank_start]haemophilia[blank_end] Increased tendency to form clots is called [blank_start]thrombophilia[blank_end]
Answer
  • thrombophilia
  • haemophilia
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