Myeloma and Other Plasma Cell Disorders

Matthew Coulson
Quiz by Matthew Coulson, updated more than 1 year ago
Matthew Coulson
Created by Matthew Coulson about 2 years ago
4
1

Description

Multiple Myeloma, AL Amyloidosis, MGUS and Waldenstrom's Macroglobulinaemia

Resource summary

Question 1

Question
Immunoglobulins are antibodies produced by B cells/Plasma cells that are made up of [blank_start]2[blank_end] heavy chains and [blank_start]2[blank_end] light chains
Answer
  • 2
  • 1
  • 3
  • 2
  • 1
  • 3

Question 2

Question
Which of the immunoglobulins has a pentameric structure?
Answer
  • IgM
  • IgG
  • IgA

Question 3

Question
Which of the immunoglobulins has a dimeric structure?
Answer
  • IgM
  • IgA
  • IgG

Question 4

Question
Which of the immunoglobulins have monomeric structures?
Answer
  • IgM
  • IgG
  • IgA
  • IgE
  • IgD

Question 5

Question
[blank_start]Plasma[blank_end] cells have an eccentric 'clock face nucleus' on H&E Stain
Answer
  • Plasma

Question 6

Question
Plasma cells are characterised by their [blank_start]open[blank_end] chromatin
Answer
  • open
  • closed

Question 7

Question
Monoclonal immunoglobulins are all derived from clonal expansion of one single B cell. Monoclonal immunoglobulins are also known as [blank_start]paraproteins[blank_end]
Answer
  • paraproteins

Question 8

Question
Paraproteins = [blank_start]Monoclonal[blank_end] Immunoglobulins
Answer
  • Monoclonal
  • Polyclonal

Question 9

Question
Paraproteins are a marker of an underlying clonal B cell disorder
Answer
  • True
  • False

Question 10

Question
What is the best form of investigation for detecting Paraproteins
Answer
  • Immunophenotyping by Flow Cytometry
  • Serum Electrophoresis
  • Fluorescence In-Situ Hybridisation
  • Cell Morphology

Question 11

Question
Paraproteins found on Serum Electrophoresis tend to present in the [blank_start]Gamma[blank_end] band
Answer
  • Gamma
  • Beta
  • Albumin
  • Alpha-1
  • Alpha-2

Question 12

Question
After serum electrophoresis has been conducted to detect paraproteins, serum [blank_start]immunofixation[blank_end] should then be conducted in order to classify the abnormal protein band
Answer
  • immunofixation

Question 13

Question
Bence Jones Protein is a monoclonal immunoglobulin light chain which is detected by [blank_start]urine[blank_end] electrophoresis
Answer
  • urine
  • serum
  • bone marrow
  • CSF

Question 14

Question
The presence of Bence Jones Protein in the urine is suggestive of which two of the following conditions?
Answer
  • Multiple Myeloma
  • Waldenström's Macroglobulinemia
  • Monoclonal Gammopathy of Undetermined Significance (MGUS)
  • Alpha heavy chain disease
  • Acute Lymphoblastic Leukaemia

Question 15

Question
Which of the following is most common condition causative of paraproteinaemia?
Answer
  • Multiple Myeloma
  • Monoclonal gammopathy of undetermined significance (MGUS)
  • Waldenstrom's Macroglobulinemia

Question 16

Question
Monoclonal gammopathy of undetermined significance (MGUS) is a benign (premalignant) condition which can predispose to Multiple Myeloma
Answer
  • True
  • False

Question 17

Question
Myeloma causes [blank_start]renal[blank_end] failure and increased [blank_start]bone breakdown[blank_end]
Answer
  • bone breakdown
  • blood pressure
  • erythrocytosis
  • sodium levels
  • renal
  • liver
  • heart

Question 18

Question
Myeloma is classified based on which type of monoclonal antibody is produced. What is the most common type of Myeloma?
Answer
  • IgG Myeloma
  • IgE Myeloma
  • IgA Myeloma
  • IgD Myeloma
  • IgM Myeloma

Question 19

Question
Due to bone breakdown occurring as part of Myeloma, it also typically causes raised [blank_start]Calcium[blank_end] levels in the blood
Answer
  • Calcium
  • Sodium
  • Potassium
  • Phosphate

Question 20

Question
The paraproteins in Myeloma bring about renal failure by blocking the renal [blank_start]tublues[blank_end]
Answer
  • tubules

Question 21

Question
Paraproteins blocking the renal tubules as part of Myeloma forms small aggregations leading to what is known as [blank_start]cast[blank_end] nephropathy
Answer
  • cast

Question 22

Question
Myeloma tends to affect those in their [blank_start]60s[blank_end]
Answer
  • 60s
  • 40s
  • 20s
  • teens

Question 23

Question
Levels of [blank_start]paraprotein[blank_end] in the blood should be monitored in order to monitor the response of a Myeloma patient to Chemotherapy.
Answer
  • paraprotein

Question 24

Question
Which of the following should be avoided in Myeloma patients?
Answer
  • NSAIDs
  • Amoxicillin
  • Antipsychotics
  • Antiemetics
  • Paracetamol

Question 25

Question
Which drug type should be given to myeloma patients in order to correct their hypercalcaemia and reduce their bone pain? [blank_start]Bisphosphonates[blank_end]
Answer
  • Bisphosphonates

Question 26

Question
Monoclonal gammopathy of undetermined significance (MGUS) can be diagnosed when there is a paraprotein level of [blank_start]<30g/l[blank_end] and a bone marrow plasma cell level of [blank_start]<10%[blank_end]. There must also be no evidence of any end organ damage (e.g. renal failure, bone marrow failure, etc)
Answer
  • <30g/l
  • <20g/l
  • <50g/l
  • <60g/l
  • <10%
  • <20%
  • <30%
  • <40%
  • <50%

Question 27

Question
A plasma cell immunoglobulin disorder is suspected in a patient. When a sample from the patient was stained using Congo Red and placed under polarising light it showed an 'apple-green' birefringence. What condition is the patient suffering from? [blank_start]AL Amyloidosis[blank_end]
Answer
  • AL Amyloidosis

Question 28

Question
Waldenstrom’s macroglobulinaemia is a condition which characteristically involves [blank_start]IgM[blank_end] Paraproteins
Answer
  • IgM
  • IgG
  • IgA
  • IgE
  • IgD
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