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transplant and reproductive immunology

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Medicine Quiz on transplant and reproductive immunology, created by mariam Butt on 07/07/2021.
mariam Butt
Quiz by mariam Butt, updated more than 1 year ago
mariam Butt
Created by mariam Butt almost 3 years ago
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Resource summary

Question 1

Question
The graft is a graft from 1 place to another in the same individual
Answer
  • right
  • wrong

Question 2

Question
Should blood group compatibility between donor and recipient be determined before kidney transplantation
Answer
  • yes
  • no

Question 3

Question
3. Classical MHC class II antigens (HLA-DR, DQ) have a more limited distribution than MHC class I antigens
Answer
  • yes
  • no

Question 4

Question
4. The most suitable cells for HLA compatibility testing are lymphocytes derived from the patient's peripheral blood
Answer
  • yes
  • no

Question 5

Question
After blood transfusions, pregnancy and previous transplants can form circulating antibodies
Answer
  • yes
  • no

Question 6

Question
The acute rejection reaction of the transplanted organ is manifested:
Answer
  • 3 years
  • 5-6 months
  • up to 3 months
  • up to 1-2 weeks

Question 7

Question
Rejection of the transplant is a manifestation of
Answer
  • Cell-mediated immunity
  • An important process in allograft rejection is humoral-mediated immunity
  • Hypersensitivity of type 3 (immune complexes)
  • Complement-dependent cytotoxicity
  • can damage the graft through its prancreatic enzymes.
  • The immune response to the allograft may also include antibodies- igD

Question 8

Question
Graft reaction against the host (GVH)
Answer
  • -It manifests itself in different MHC antigens between donor and recipient
  • GVH response does require suppressor T cells
  • -May be the result of an infusion of blood products containing viable lymphocytes into immunologically incompetent recipient
  • (GVH) is caused by the destruction of cells or tissues of immunocompetent recipient of immunocompetent stem cells

Question 9

Question
During transplantation, the preformed cytotoxic antibodies in the recipient
Answer
  • Are responsible for the super-sharp rejection
  • Cytotoxic antibodies of class IgA and IgD lead to an over-acute rejection reaction
  • Can be directed against HLA or ABO antigens of the graft
  • all are correct

Question 10

Question
Immunological follow-up of an organ transplant patient requires examination of
Answer
  • Changes in lymphocyte populations and subpopulations
  • n acute rejection is dominated by CD3 + T lymphocytes
  • Donor-specific AT
  • Serum levels of cytokines
  • serum levels of interferons

Question 11

Question
In recipients with repeated kidney transplants, graft survival compared to that in recipients with a first kidney transplant is:
Answer
  • reduced
  • increased
  • recurrent antigenic incompatibilities (especially DR) between donor and recipient in repeated kidney transplants have a positive effect on graft survival.

Question 12

Question
Prevention of hemolytic disease of the newborn due to compatibility with maternal Rhesus (RhD) factor includes
Answer
  • passive maternal immunization to remove Rh antigen
  • active maternal immunization to remove Rh antigen
  • infusion done after 72hours after the first birth
  • infusion of anti-RhD antibodies to the Rh (+) mother

Question 13

Question
If the mother develops IgG AT to A and B erythrocyte antigens of the fetus, hemolytic disease of the newborn will appear in children from:
Answer
  • - 0 mother and AB father
  • AB mother and 0 father
  • A mother and ab father
  • 0 mother and A father

Question 14

Question
Which of the following AGs are rich in cell membranes of B-lymphocytes
Answer
  • MHC class II antigens
  • MHC class I antigens
  • all are correct
  • none are correct

Question 15

Question
Class III MHC regions in the major human tissue compatibility complex contain genes which encode
Answer
  • - components of the complement system
  • heat shock proteins and cytokines
  • none are correct
  • components of cellular immunity

Question 16

Question
Antimetabolites that suppress the immune response are the purine antagonists are
Answer
  • involved in dna synthesis
  • mercapturin
  • azathioprine
  • involved in mRna synthesis

Question 17

Question
Hypersensitivity graft rejection is associated with
Answer
  • preformed cytotoxic antibodies
  • complement activation
  • cellular immunity
  • nantural resistance

Question 18

Question
The accelerated rejection reaction involves the following immunological factors and mechanisms of
Answer
  • sensitized T cells preformed by HLA AT formed during immune response to graft or AZKC
  • activated b cells
  • complement system
  • all are correct

Question 19

Question
Molecular genetic methods for HLA typing in clinical transplant practice include
Answer
  • elisa
  • electrophoresis
  • immunoblot
  • pcr

Question 20

Question
The cells infiltrating the graft in the acute rejection reaction are predominantly
Answer
  • CD4 +
  • CD3 +
  • CD16 +
  • CD8+

Question 21

Question
Allogeneic transplantation
Answer
  • bone marrow transplantation from mother to daughter
  • bone marrow transplantation from daughter to mother
  • bone marrow transplantation from mother to son
  • bone marrow transplantation from father to daughter

Question 22

Question
Autologous transplantation
Answer
  • transplantation of skin from the thigh to the face of the same individual
  • transplantation of skin from the thigh to the face of the different individual
  • transplantation of skin from the thigh of a twin to the face of the other twin individual
  • done to replace cicatrix for cosmetic procedure

Question 23

Question
Syngenna
Answer
  • bone marrow transplantation from same individual
  • bone marrow transplantation between twins
  • bone marrow transplantation between family members
  • bone marrow transplantation between two compatible donor and recipient

Question 24

Question
Sources of stem cells
Answer
  • serum
  • peripheral blood
  • pancreas
  • umbilical cord
  • bone marrow
  • epiphysis

Question 25

Question
Gene loci of the HLA-class II region (3 correct)
Answer
  • dp
  • rt
  • dq
  • dr
  • ds
  • located in the long arm of the sixth chromosome in humans

Question 26

Question
Hormones: luteinizing (LH), follicle-stimulating (FSH), inhibin B and estradiol, are tested in serum to assess ovarian reserve in women with reproductive disorders
Answer
  • yes
  • no

Question 27

Question
Recurrent abortions are not associated with defects in coagulation factors or circulating anticoagulants (lupus-like anticoagulants)
Answer
  • correct
  • incorrect

Question 28

Question
Women with positive anti-ovarian antibodies have an increased chance of becoming pregnant after birth control in vitro fertilization or embryo transfer compared to women in whom no such was found antibodies
Answer
  • no
  • yes

Question 29

Question
Antibodies in women with reproductive disorders are tested by serum
Answer
  • yes
  • no

Question 30

Question
Antiphospholipid syndrome is associated with the presence of anticardiolipin antibodies, loss of fetal, arterial and venous thrombosis
Answer
  • no
  • yes

Question 31

Question
which hormone is secreted by the granulosa cells of the ovary and controls the series of follicle-stimulating hormone from the pituitary gland
Answer
  • fsh
  • lh
  • inhibin b
  • estradiol

Question 32

Question
Which immune indicators are associated with premature decline in ovarian function
Answer
  • rbc,wbc,anti-dna
  • ca19-9, anti phospholipid,antithyroid
  • - antiphospholipid, antinuclear, antithyroid and anti-ovarian AT
  • none of the above

Question 33

Question
The study of the reproductive immunophenotype in women with reproductive problems includes
Answer
  • T-lymphocytes CD3 +, CD4 +, CD8 +
  • B-lymphocytes CD19 +
  • NK cells CD3 CD56 +, CD16 +

Question 34

Question
Immunological manifestations in patients with endometriosis and reproductive problems are demonstrated
Answer
  • increased serum levels of antiphospholipid and antinuclear antibodies
  • activated reproductive phenotype and increased NK-cell cytotoxicity
  • increase in CA125

Question 35

Question
In patients with previous abortions, monitoring and prognosis of the current pregnancy includes a study of serum concentrations of
Answer
  • FSH
  • - beta human chorionic gonadotropin
  • LH
  • pituitary gland

Question 36

Question
HLA-G antigens are expressed in
Answer
  • myoblast
  • osteoblasts
  • trophoblasts
  • lymphokines

Question 37

Question
The main functions of HLA-G antigens are (SPECIFY THE WRONG ANSWER)
Answer
  • inhibiting the antitrophoblast activity of maternal NK cells
  • protecting the fetus from the mother's immune response against the paternal antigens in it
  • inducing frequent abortions
  • protection of the fetus from transplant infections

Question 38

Question
Elevated NK cells in women with frequent abortions (SPECIFY THE WRONG ANSWER)
Answer
  • secrete tumor necrosis factor (TNF)
  • are examined by peripheral venous blood in an anticoagulant
  • are cytotoxic to the placental trophoblast
  • they don't matter

Question 39

Question
The immunological examination of anti-phospholipid syndrome in pregnant women includes
Answer
  • - anticardiolipin antibodies
  • -antibodies to phosphatidylethanolamine, phosphatidylinositol, phosphatidic acid, phosphatidylglycerol, phosphatidylserine, phosphatidylcholine
  • anti-beta-2-glycoprotein I AT

Question 40

Question
Anti-ovarian antibodies include AT versus (2 correct)
Answer
  • antigens of the pellucid zone
  • antigens of steroid-producing granulosa-luteinizing cells
  • Antibodies against the pellucid zone are also important in specifying cases of cervical cancer
  • Antibodies against the pellucid zone are also important in specifying cases of cystic disease.

Question 41

Question
The normal development of pregnancy is due to the predominance of
Answer
  • Th1 cytokines
  • Th2 cytokines
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