Quiz
Antihelminths/Antibacterials/Antifungal/Antiviral/Antimicrobial Susceptibility Testing
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Questions in this quiz (68)
1Select all that apply. Which of the following are β-lactamase penicillins?
- AAmpicillin
- BTicarcillin
- CMethicillin
- DPiperacillin
- ENafcillin
- FAmoxicillin
2What does PBP1A bind to?
- ATranspeptidase
- BCarboxypeptidase
- CEndopeptidase
3Penicillin G is stable in gastric acid.
- ATrue
- BFalse
4Which of the following penicillins have rapid elimination times less than or equal to 90 minutes?
- APenicillin G
- BNafcillin
- CAmpicillin
- DPiperacillin
- EAmoxicillin
- FAll of the above
5One RARE side effect of Penicillin G K+ is [blank_start]_______________[blank_end].
- Ahyperkalemia
6Select all that apply. The mechanism of action for penicillins are:
- Aconcentration dependent bactericidal action
- Btime dependent bactericidal action
- Cworks best against rapidly dividing bacteria
- Dworks best against slowly dividing bacteria
- Einhibits transpeptidase activity of PBP3
7Which of the following cause neutropenia?
- APenicillin V
- BPiperacillin
- CPenicillin G
- DAmoxicillin-Clavulanic Acid Combo
- EVancomycin
- FA, B, and D
- GA and C
- HB, C, and E
8Which of the following is the correct mechanism for how Polymyxins act as antibiotics?
- ABinds to ribosome 30s to prohibit protein synthesis
- BDisrupts the integrity of the baceterial cell wall by displacing calcium and magnesium
- CInhibits the cross-linkages between the peptidoglycan polymer strands
- DDisrupts the integrity of the cell membrane by displacing calcium and magnesium
9Which bacteria are susceptible to enzyme inactivation by beta lactamases?
- ACephalosporins
- BMacrolides
- CMetronidazole
- DTetracyclines
10Penicillins are narrow spectrum drugs
- ATrue
- BFalse
11Select all of the bactericidal antibiotics.
- AMacrolides
- BPenicillin
- CTetracycline
- DCephalexin
- EAminoglycosides
- FClindamycin
12Which of the following is NOT a concern of antibiotic (antibacterial specifcially) use?
- AStevens Johnsons
- BSuperinfection
- CTeratology
- DIncreased effects of oral contraceptives
13Which of the following is incorrect regarding Penicillin G/Penicillin V
- AUsed for mixed aerobic-anaerobic infections
- BUsed against gram positive and gram negative bacteria
- COne of these two can be used for treatment of Rheumatic fever
- DThese are all correct
14Which of the following is not an antistaphylococcal penicillin?
- AAmoxicillin
- BMethicillin
- CNafcillin
- DThese are all antistaphylococcal penicillins
15Penicillins work by inhibiting with enzyme?
- AIntegrase
- BPeptidyl transferase
- CTranspeptidase
- DTranscriptase
16Penicillin V is administered by IV only
- ATrue
- BFalse
17Which of the following is NOT a possible adverse effect from penicillins?
- AAllergy
- BPhlebitis
- CFungal overgrowth
- DHemolytic anemia
18Which of the following is true regarding aminopenicillins?
- AResistant to beta lactamases
- BNarrow spectrum
- CAmpicillin has less side effects than amoxicillin
- DEffective against gonorrhea and meningitis
19Select the following that are ineffective against beta lactamases:
- APenicillin V
- BPenicillin G
- CDicloxacillin
- DAmoxicillin
20Which of the following best represents first generation cephalosporins?
- AIncludes Cefotaxime and Ceftriaxone
- BUsed for UTI (urinary tract infections) and soft tissue abscesses
- CEffective against Klebsiella and H influenza
- DUsed for treatment of community-acquired pneumonia
21Which of the following best describes the second generation of cephalosporins?
- ADrug of choice for surgical prophylaxis
- BUsed to treat meningitis
- CIncludes the drug Cefuroxime
- DIncludes the drug Cefepime
22Protein synthesis inhibitors are considered narrow spectrum antibiotics
- ATrue
- BFalse
23Tetracyclines are broad spectrum antibiotics
- ATrue
- BFalse
24Which of the following best matches the mechanism of tetracyclines?
- AInhibition of beta 1-3 glycan of bacterial cell wall, preventing cross linkages
- BBecomes mechanically reduced to toxic metabolite, interacting with DNA
- CBinds to 50s subunit, preventing binding of tRNA to mRNA
- DBinds to 30s subunit, preventing binding of tRNA to mRNA
25Which of the following are targeted by tetracyclines?
- ARickettsia
- BMRSA infections
- CP. vivax malaria
- DAll are targeted by tetracyclines
26Which of the following is INCORRECT regarding macrolides?
- ABroad spectrum
- BUsed as an alternative for patients allergic to penicillins
- CCan be bacteriostatic or bacteriocidal, depending on dose (concentration)
- DKills gram positive and gram negative bacteria
27Which of the following is incorrect regarding Chloramphenicol?
- AIt is bacteriostatic
- BBinds to 50s ribosome
- CCan be used to treat typhoid fever
- DCan be used for Neisseria gonorrhea
28Chloramphenicol can cause gray baby syndrome.
- ATrue
- BFalse
29Which of the following is NOT a use for Clindamycin?
- APseudomembranous colitis
- BAnthrax
- CToxic shock syndrome
- DOdontogenic infection
30Which of the following is NOT a concern for use of Clindamycin?
- ANeuromuscular block
- BSkin rashes
- CPseudomembranous colitis
- DFulminant hepatic necrosis
31What is the clinical use of sulfonamides?
- ASkin infections
- BUTI (urinary tract infections)
- CAlternative for patients allergic to penicillins
- DPseudomembranous colitis
32Sulfonamide is a structural analog of DFHR
- ATrue
- BFalse
33Sulfonamides can cause which of the following adverse effects?
- APhotosensitivity
- BPseudomembranous colitis
- CNeutropenia
- DSeizures
34Clotrimazole can be used for UTI (urinary tract infections)
- ATrue
- BFalse
35How do fluoroquinolones kill bacteria?
- AThey bind to topoisomerase-DNA complexes and form an inactive complex
- BThey bind to bacterial ribosomes 30s
- CThey inhibit transpeptidases
- DThey compromise the integrity of the bacterial cell membrane
36Which of the following can cause Red Man Syndrome?
- APenicillin
- BErythromycin
- CVancomycin
- DSulfamethoxazole
37Which of the following is NOT a side effect of drugs such as gentamicin, tobramycin, and amikacin?
- Anephrotoxicity
- Bvestibular toxicity
- Ctooth discoloration
- Dcochlear toxicity
38Which of the following cannot be used to treatment of MRSA?
- ALinezolid
- BVancomycin
- CStreptogramins
- DClindamycin
39MRSA is resistant to ALL penicillins and cephalosporins
- ATrue
- BFalse
40Which of the following does NOT increase risk of nephrotoxicity?
- AAminoglycosides
- BAmphoterecin B
- CCisplatin
- DMacrolides
41Nystatin is not related to Amphoterecin B and can therefore be used systemically.
- ATrue
- BFalse
42What type of fungal infection does nystatin treat?
- ACryptococcal meningitis
- BCandida infections
- CHistoplasmosis
- DAsperillosis
43Choose all of the trizoles.
- AKetoconazole
- BItraconazole
- CFluconazole
- DVoriconazole
- EMiconazole
- FClotrimazole.
44What is the correct mechanism of azoles?
- ADisrupts microtubule function and inhibits dermatophyte growth
- BBinds to membrane Ergosterol
- CInhibits viral DNA polymerase
- DInhibits the lanosterol 14 alpha enzyme, preventing the conversion of lanosterol to ergosterol and disrupts the struction of fungal membrane
45Which of the following is NOT an adverse effect of Azoles
- ASteven Johnson
- BIncreased levels of warfarin
- CDecreased fluconazole levels with isoniazid
- DNephrotoxicity
46Which of the following antifungals are used to disrupt microtubule (spindle) function?
- ATerbinafine
- BGriseofulvin
- CEchinocandins
- DKetoconazole
47Which of the following antifungals is used for onychomychosis and tinea?
- AGriseofulvin
- BTerbinafine
- CEchinocandins
- DKetoconazole
48Which antiviral drug prevents formation of DNA chain by inhibiting viral DNA synthesis?
- AAcyclovir
- BGanciclovir
- CRaltegravir
- DRetrovir
49Ganciclovir causes myelosuppression
- ATrue
- BFalse
50What is the therapeutic use for Penicillin?
- ADrug of choice for streptococci, pneumococcal, and staphylococcal infections
- BTreat infections due to bacteria that have developed resistance to earlier generations of cephalosporins
- CTreatment of a broad range of gram positive and gram negative organisms
- DTreatment of patients who are unable to tolerate penicillins
51What is the pharmacological class for Penicillin G?
- AAminoglycoside, protein synthesis inhibitor
- BFluroquinolone, bacterial DNA synthesis inhibitor
- CNatural penicillin, cell wall inhibitor, beta lactam
- DMycolic acid inhibitor
52What is the pharmacological class of Cefotaxime?
- ABeta lactam antibiotic, cell wall inhibitor
- BTetracycline, protein synthesis inhibitor
- CMacrolide, protein synthesis inhibitor
53Mechanism of action for Cefotaxime?
- AInhibits cell wall synthesis
- BInhibits bacterial protein synthesis and prevents replication
- CInhibits synthesis of mycolic acid
54Tetracycline mechanism of action?
- AInhibits bacterial protein synthesis and prevents cell replication
- BInhibits bacterial gyrase
- CInhibits cell wall synthesis
55What is the pharmacologic class for erythromycin?
- AMacrolide, protein synthesis inhibitor
- BAminoglycoside, protein synthesis inhibitor
- CBeta lactam antibiotic
56What is the mechanism of action for erythromycin?
- AInhibits protein synthesis
- BInhibits cell wall synthesis
- CBinds to peptidoglycan
- DInhibits bacterial protein synthesis and prevents cell replication
57What is the pharmacologic class for gentamicin?
- AFluoroquinolone
- BSulfonamide, folic acid inhibitor
- CAminoglycoside, protein synthesis inhibitor
- DMycolic acid inhibitor
58What is the mechanism of action for Gentamicin?
- AInhibits bacterial metabolism of folic acid
- BInhibits protein synthesis, disrupting cell membrane and killing bacteria
- CInhibits synthesis of mycolic acids
- DInhibits bacterial DNA gyrase, interfering with bacterial replication and DNA error
59Which of the following drugs would be used as treatment of UTI, GI, STDs, soft tissue, bone and joint infections?
- ATrimetoprim-sulfamethoxazole
- BCiprofloxacin
- CIsoniazid
- DGentamicin
60What is the pharmacological class and mechanism of action for ciprofloxacin?
- AFluoroquinolone, inhibits bacterial DNA gyrase
- BMycolic acid inhibitor, inhibits mycolic acid
- CAminoglycoside, inhibits protein synthesis
- DSulfonamide, inhibits bacteiran metabolism of folic acid
61Which drug would be used as a treatment for urinary tract infections, nocardiosis infections, and toxoplasmosis?
- ACiprofloxacin
- BGentamicin
- CPenicillin
- DTrimethoprim-sulfamethoxazole
62What is the mechanism of action and pharmacological class for trimethoprim-sulfamethoxazole?
- Afluroquinolone, inhibits bacterial DNA gyrase
- Bsulfonamide, inhibits bacterial metabolism of folic acid
- Caminoglycoside, inhibits protein synthesis, disrupts membrane, kills bacteria
63Which of the following drugs is a broad spectrum treatment of a wide range of helminth infections?
- AMebendazole
- BAmphotericin B
- CFluconazole
- DCloroquine
64What is the mechanism of action for Mebendazole?
- AConcentrates in food vacuoles of plasmodium residing in red blood cells
- BInhibits microtubule formation and glucose uptake
- CBinds to ergosterol in fungal cell membranes and causes them to leak
- DInterferes with ergosterol synthesis
65What is the therapeutic class for Amphotericin B?
- AAntihelminth
- BAntifungal
- CAntifungal (systemic)
- DAntimalarial
66Which of the following drugs is the treatment of most fungi pathogenic to humans, the preferred drug for most systemic mycoses?
- AFluconazole
- BCloroquine
- CMebendazole
- DAmphotericin B
67Select all the following drugs that are polyenes.
- AAmphotericin B
- BEchinocandin
- CGriseofulvin
- DNystatin
68What is the therapeutic class for the drug Fluconazole?
- AAntihelminth
- BAntifungal
- CAntibacterial
- DAntiviral
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- Zainab Hassoun
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