5251941
Description
Quiz by Jeku Jacob, updated more than 1 year ago
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Created by Jeku Jacob
almost 8 years ago
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Question 1
Question
Which of the following mechanisms best describes the mode of action of the sulphonylurea class of drugs?
Answer
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Stimulates insulin synthesis.
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Enhances insulin binding to the beta cell insulin receptor.
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Stimulates insulin secretion.
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Stimulates conversion of proinsulin to insulin and C-peptide.
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Stimulates beta cell proliferation.
Question 2
Question
The deterioration in glycaemic control over time seen in patients with type 2 (non-insulin-dependent) diabetes mellitus is primarily due to:
Answer
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medication non-compliance.
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increasing insulin resistance.
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increasing obesity.
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decreasing insulin secretion.
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reduced energy expenditure
Question 3
Question
Which of the following drugs used in diabetes treatment is most likely to cause hypoglycemia?
Answer
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Repaglinide.
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Metformin.
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Acarbose.
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Rosiglitazone.
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Orlistat.
Question 4
Question
In a patient with Type 2 diabetes which of the following co-existing clinical situations is the strongest contraindication to the use of a thiazolidinedione drug?
Answer
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Fatty liver disease.
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Peripheral vascular disease.
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Severe congestive cardiac failure.
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Proliferative diabetic retinopathy.
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Serum creatinine 200μmol/L.
Question 5
Question
In patients with Type 1 Diabetes, the greatest benefit in using a long acting insulin analogue is in reducing which of the following
Answer
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Diabetic Retinopathy
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Nocturnal hypoglycemia
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insulin hypersensitivity
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preprandial hyperglycemia
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microalbuminuria
Question 6
Question
Glucagon-like peptide–1, secreted postprandially by the L-cells in the intestine, increases which of the following?
Answer
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Gastric emptying.
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Body weight.
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Insulin secretion.
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Hepatic glucose output.
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Insulin sensitivity (sulphonylurea, thiazolidinediones)
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