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Anti-Diabetic Drugs Quiz

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NAPLEX Pharmacy (Endo) Quiz on Anti-Diabetic Drugs Quiz , created by Mark W. on 12/12/2016.
Mark W.
Quiz by Mark W., updated more than 1 year ago
Mark W.
Created by Mark W. over 7 years ago
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Resource summary

Question 1

Question
Which of the following drugs are the only medications approved for the use in the treatment of Type 1 DM?
Answer
  • Pramlintide (Symlin)
  • Miglitol (Gylset)
  • Insulin
  • Pioglitazone (Actos)

Question 2

Question
Increntin hormones like GLP-1 and GIP stimulate insulin secretion in response to meals
Answer
  • True
  • False

Question 3

Question
Specify how each of the following specified areas contribute to the pathophysiology of Type 2 DM
Image:
3fd29a0a-68e2-4231-9e17-46c57c2433c1 (image/png)
Answer
  • decreased glucose uptake
  • decreased incretin effect
  • increased lipolysis
  • decreased insulin secretion (beta cells)
  • decreased glucose uptake
  • increased production of glucose
  • neurotransmitter dysfunction
  • increased glucagon secretion
  • increased lipolysis
  • decreased glucose uptake
  • increase production of glucose
  • increase glucose reabsorption
  • neurotransmitter dysfunction
  • increased glucose reabsorption
  • decreased incretin effect
  • increase glucagon secretion
  • neurotransmitter dysfunction
  • increased lipolysis
  • decrease glucose uptake
  • increased production of glucose
  • increased glucagon secretion (alpha cell
  • decreased glucose uptake
  • increased glucose reabsorption
  • increased lipolysis
  • decreased glucose uptake
  • increased production of glucose
  • decreased incretin effect
  • increased glucagon secretion (alpha)
  • decreased insulin secretion (beta cells)
  • increased glucagon secretion (alpha cell
  • decreased incretin effect
  • increased lipolysis

Question 4

Question
Pramlintide (Symlin) belongs to what drug class?
Answer
  • alpha-glucosidase inhibitors
  • amylinomimetics
  • Megltinides
  • Sulfonylureas

Question 5

Question
What type of efficacy does the following anti-diabetic drugs have? Metformin, Sulfonyureas, TZDs, GLP-1
Answer
  • Low efficacy (< 0.5 decrease in A1C)
  • Intermediate efficacy (~0.5-1 % decrease in A1C)
  • High efficacy ( ~1-2% decrease in A1C)

Question 6

Question
What type of efficacy do the following drugs have? SGLT2, DPP-IV, Alpha-glucosidase inhibitors
Answer
  • High efficacy (~1-2% decrease in A1C)
  • Intermediate efficacy (~0.5-1% decrease in A1C)
  • Low efficacy (< 0.5% decrease in A1C)

Question 7

Question
Of the following anti-diabetic drugs, which have the lowest efficacy in regards to the lowering of the A1C?
Answer
  • Colesvelam
  • Metformin
  • Insulins
  • Bromocriptine

Question 8

Question
[blank_start]Pramlintide (Symlin)[blank_end] has a BBW for severe HYPOglycemia
Answer
  • Pramlintide

Question 9

Question
Which of the following are contraindications for Pramlintide (Symlin)?
Answer
  • gastroparesis
  • HYPOglycemic unawareness
  • poor compliance with drug insulin regimens
  • pediatric patients
  • inflammatory bowel disease
  • colonic ulceration

Question 10

Question
If taking anti-diabetic drug [blank_start]Pramlintide (Symlin)[blank_end], the meal time insulin must reduced by 50%.
Answer
  • Pramlintide

Question 11

Question
Pramlintide (Symlin) must be injected immediately prior to each major meal.
Answer
  • True
  • False

Question 12

Question
Miglitol (Glyset) and Acarbose (Precose) belong to what anti-diabetic drug class?
Answer
  • Amylinomimetics
  • alpha-glucosidase inhibitors
  • Biguanides
  • TZD's

Question 13

Question
What is the MOA for the alpha-glucosidase inhibitors?
Answer
  • activation of amylin
  • activates the nuclear transcription factor PPAR-gamma
  • inhibits intestinal alpha glucosidase
  • activates GLP-1 receptors

Question 14

Question
The [blank_start]alpha-glucosidase[blank_end] drug class slows intestinal carbohydrate digestion/absorption.
Answer
  • alpha-glucosidase
  • secretagogues
  • TZDs
  • Biguanides

Question 15

Question
Alpha-glucosidase drugs must be taken with the 1st bite of each meal
Answer
  • True
  • False

Question 16

Question
Which of the following are adverse drug reactions for alpha-glucosidase class?
Answer
  • GI disturbances
  • flatulence
  • headache
  • elevation in hepatic enzymes

Question 17

Question
Contrainidcations for the [blank_start]alpha-glucosidase inhibitors[blank_end] include inflammatory bowel disease, colonic ulceration, intestinal obstruction, malabsorption, and CrCL < 25 mL/min
Answer
  • alpha-glucosidase inhibitors
  • amylinomimetics
  • DPP-IV
  • Meglitinides

Question 18

Question
Hypoglycemia must be treated with what when taking an alpha glucosidase inhibitor.
Answer
  • complex carbs
  • insulins
  • simple carbohydrates

Question 19

Question
Which of the following are the mechanisms of action for the biguanides class?
Answer
  • decrease glucose production from the liver
  • closes a K(ATP) channels on beta-cell plasma membranes
  • increases insulin sensitivity in muscle
  • decrease carbohydrate uptake in gut

Question 20

Question
Which of the following are the mechanisms of action for the biguanides class?
Answer
  • closes K(ATP) channels on beta-cell plasma membranes
  • decreases glucose production form liver
  • increases insulin sensitivity in muscle
  • decreases uptake in gut

Question 21

Question
What is the physiological action of the Biguanides class?
Answer
  • increases insulin secretions
  • decreases hepatic glucose production
  • increases incretin levels
  • decreases glucagon secretion

Question 22

Question
The maximum effective does for Metformin (Glucophage) is [blank_start]2000[blank_end] mg/day
Answer
  • 2000
  • 1500
  • 1000
  • 2250

Question 23

Question
Metformin (Glucophage) has a BBW for lactic acidosis
Answer
  • True
  • False

Question 24

Question
Iodinated contrast media, unstable HF, eGFR < 30 mL/min, hepatic dysfunction, dehydration, pre-renal azotemia, hypoxic states, CKD, and acidosis are all contraindications for [blank_start]Metformin (Glucophage)[blank_end]
Answer
  • Metformin

Question 25

Question
[blank_start]Metformin (Glucophage)[blank_end] is the first line therapy for T2DM.
Answer
  • Metformin

Question 26

Question
Starting metformin in patients with an eGFR between 45-50 mL/min/1.73m is not recommended.
Answer
  • True
  • False

Question 27

Question
The following drugs belong to what class? Glyburide (Micronase) Glyburide (Micronized) - (Glynase) Glipizide (Glucotrol) Glimepiride (Amaryl)
Answer
  • Biguanides
  • DDP-IV
  • TZD's
  • Sulfonylureas

Question 28

Question
Closure of the K(ATP) channels on beta-cell plasma membranes is the MOA for what class(es) of drugs?
Answer
  • Sulfonylureas
  • TZDs
  • Bile Acid sequestrants
  • Meglitinides

Question 29

Question
Which of the following are ADR's for the sulfonylurea class?
Answer
  • HYPOglycemia
  • SIADH
  • photosensitivity
  • GI disturbances
  • B12 deficiency
  • induced ovulation in PCOS
  • sulfa-allergy

Question 30

Question
[blank_start]Sulfonrylureas[blank_end] should NOT be used in elderly patients or patients with hepatic impairment
Answer
  • Sulfonylureas

Question 31

Question
Which of the sulfonylureas can be used during pregnancy?
Answer
  • Glyburide (Micronase)
  • Glipizide (Glucotrol)
  • Glimepiride (Amaryl)

Question 32

Question
For the sulfonylurea class, 1/2 of the max dose is equal to 80% drug effectiveness
Answer
  • True
  • False

Question 33

Question
Sulfonylureas can be used in combination with insulin
Answer
  • True
  • False

Question 34

Question
Glynase can be interchanged with the drug Mirconase.
Answer
  • True
  • False

Question 35

Question
Of the sulfonylureas, [blank_start]Glipizide (Glucotrol)[blank_end] should be utilized in patients with renal impariement.
Answer
  • Glipizide

Question 36

Question
Which of the following drugs are Meglitinides?
Answer
  • Nateglinide (Starlix)
  • Pioglitazone (Actos)
  • Repaglinide (Prandin)
  • Rosiglitazone (Avandia)

Question 37

Question
Which of the following are ADR's for the Meglitinides?
Answer
  • increased fluid retention
  • bladder cancer
  • HYPOglycemia
  • dizziness
  • GI disturbances

Question 38

Question
[blank_start]Meglitinides[blank_end] can be antidiabetic drug that can be reccommended for patients who are meal skippers.
Answer
  • Meglitinides

Question 39

Question
Repaglinide (Prandin) is contraindicated with Gemfibrozil
Answer
  • True
  • False

Question 40

Question
Which drugs listed below belong the Thiazolidinediones (TZDs) class?
Answer
  • Sitagliptin (Januvia)
  • Linagliptin (Tradjenta)
  • Pioglitazone (Actos)
  • Rosiglitazone (Avandia)

Question 41

Question
What is the MOA for the Thiazolidinediones class?
Answer
  • closure of the K(ATP) channels on the beta-cell membranes
  • activates dopaminergic receptors
  • activates GLP-1 receptors
  • activates the nuclear transcription factor PPAR-gamma

Question 42

Question
What is the physiological action for the TZD class?
Answer
  • increases insulin secretion
  • increases insulin sensitivity in the skeletal muscle, adipocytes, and liver
  • decreases hepatic glucose production

Question 43

Question
[blank_start]TZDs[blank_end] have a BBW warning for heart failure
Answer
  • TZDs
  • Meglitinides
  • DPP-IV inhibitors
  • Bile Acid Sequestrants

Question 44

Question
Select the ADRs of the TZD class
Answer
  • increase in fluid retention
  • dizziness
  • peripheral edema
  • hepatotoxicity
  • bladder cancer
  • fractures
  • macular edema

Question 45

Question
Which patient should not take TZDs for their diabetes?
Answer
  • Patients with Class III or IV heart failure
  • Patient with Type 1 DM
  • Patients with the risk of bone fracture

Question 46

Question
Of the TZD drugs, which has an improved lipid profile?
Answer
  • Pioglitazone (Actos)
  • Rosiglitazone (Avandia)

Question 47

Question
TZDs can be used in combination with Metformin
Answer
  • True
  • False

Question 48

Question
[blank_start]Colesevelam (Welchol)[blank_end] is a bile acid sequestrant
Answer
  • Colesevelam

Question 49

Question
Binds bile acids in intestinal tract, increasing hepatic bile acid production and activates the farnesoid X receptor (FXR) in the liver is the MOA for what drug class?
Answer
  • Dopamine agonist
  • Bile acid sequestrant
  • DPP-IV inhibitors
  • Biguanides

Question 50

Question
Indicate the physiological actions of the bile acid sequestrant class?
Answer
  • Decreases hepatic glucose production
  • increases incretin levels
  • increases insulin sensitivity
  • activates GLP-1 receptors

Question 51

Question
Which of the following are ADR's for bile acid sequestrant?
Answer
  • constipation
  • increases in TG
  • pancreatitis
  • decreases absorption of other medications
  • GI upset
  • fatigue

Question 52

Question
Bowel obstructions, TG > 500 mg/dL, and history of hypertriglyceridemia-induced pancreatitis are contraindications for ....
Answer
  • Dopamine agonist
  • Bile acid sequestrant
  • DPP-IV
  • SGLT-2

Question 53

Question
Colesevelam (Welchol) can be approved for monotherapy
Answer
  • True
  • False

Question 54

Question
Bromocriptine (Cycloset) belongs to what anti-diabetic drug class?
Answer
  • Bile acid sequestrant
  • SGLT-2
  • Dopamine agonist
  • GLP-1

Question 55

Question
What is the MOA for Bromocriptine (Cycloset)?
Answer
  • inhibits DPP-IV activity
  • activates GLP-1 receptors
  • inhibits SGLT-2 in the proximal tubule
  • activates dopaminergic receptors

Question 56

Question
What are the physiological actions for the Dopamine agonist class?
Answer
  • modulates HYPOthalamic regulation of metabolism
  • decrease hepatic glucose production
  • increased incretin levels
  • increased insulin sensitivity

Question 57

Question
Postural hypotension, headache, fatigue, hallucinations, psychotic disorder, pleural effusion, pulmonary fibrosis, and GI ulcers are the ADR's for what drug?
Answer
  • Colesevelam (Welchol)
  • Bromocriptine (Cycloset)
  • Sitagliptin (Januvia)
  • Liraglutide (Victoza)

Question 58

Question
Which of the following are contraindications for the Bromocriptine (Cycloset)?
Answer
  • Hypersensitivity to ergot derivation or dopamine
  • lactation
  • syncopal migraines
  • severe renal impairment

Question 59

Question
Bromocriptine (Cycloset) is not approved for monotherapy.
Answer
  • True
  • False

Question 60

Question
What drug class do the following drugs belong to? Sitagliptin (Januvia) Saxagliptin (Onglyza) Linagliptin (Tradjenta) Alogliptin (Nesina)
Answer
  • DPP-IV
  • SGLT2 inhibitors
  • Dopamine agonist
  • GLP-1 agonist

Question 61

Question
Inhibits DPP-IV activity, increasing postprandial active incretin concentrations is the MOA for what drug class?
Answer
  • GLP-1
  • TZDs
  • Biguanides
  • DPP-IV inhibitors

Question 62

Question
What are the physiological actions for the DPP-IV inhibitors? (select all that apply)
Answer
  • increases insulin secretion (glucose-dependent)
  • increase renal excretion of glucose
  • decrease glucagon secretion (glucose-dependent)
  • slows gastric emptying

Question 63

Question
Of the DPP-IV inhibitors, which one does not need to be adjusted in renal and hepatic impairment?
Answer
  • Alogliptin (Nesina)
  • Linagliptin (Tradjenta)
  • Saxagliptin (Onglyza)
  • Sitagliptin (Januvia)

Question 64

Question
ADR's for DPP-IV's include which of the following
Answer
  • upper respiratory infection
  • peripheral edema
  • decreased BP
  • pancreatitis
  • SJS
  • rhabdomyolysis

Question 65

Question
FDA warns that [blank_start]DPP-4 inhibitors[blank_end] may cause severe joint pain that can be severe or diabiling
Answer
  • DPP-4 inhibitors
  • SGLT-2
  • GLP-1 inhibitors
  • TZDs

Question 66

Question
Which of the DPP-IV inhibitors can cause heart failure?
Answer
  • Sitagliptin (Januvia)
  • Saxagliptin (Onglyza)
  • Linagliptin (Tradjenta)
  • Alogliptin (Nesina)

Question 67

Question
The following drugs belong to what drug class? Exenatide (Byetta) Liraglutide (Victoza) Abiglutide (Tanzeum) Dulagultide (Trulicity)
Answer
  • GLP-1 agonist
  • TZDs
  • DPP-IV
  • SGLT-2

Question 68

Question
Select the physiological actions of the GLP-1 class
Answer
  • increases insulin secretion (glucose-dependent)
  • decreases glucagon (glucose-dependent)
  • slows gastric emptying
  • increases satiety

Question 69

Question
Of the GLP-1 agonist, which one can not be used if the CrCL is < 30 mL/min?
Answer
  • Exenatide (Byetta)
  • Liraglutide (Victoza)
  • Abiglutide (Tanzeum)
  • Dulaglutide (Trulicity)

Question 70

Question
Of the GLP-1 inhibitors, which ones have a BBW warning for thyroid carcinoma?
Answer
  • Exenatide (Byetta)
  • Liraglutide (Victoza)
  • Abiglutide (Tanzeum)
  • Dulaglutide (Trulicity)

Question 71

Question
History of pancreatitis, gastroparesis or GI disease, and caution in renal impairment are all contrainidcations for the [blank_start]GLP-1 agontist[blank_end]
Answer
  • GLP-1 agonist
  • DPP-IV
  • TZDs
  • SGLT-2

Question 72

Question
The following drugs belong to what drug class? Canagliflozin (Invokana) Dapagliflozin (Farxiga) Empagliflozin (Jardiance)
Answer
  • SGLT-2 inhibitors
  • DPP-IV
  • Biguanides
  • Meglitinides

Question 73

Question
Which of the following are ADR's for the SGLT-2 inhibitor drug class?
Answer
  • female & male genital mycotic infections
  • increased urination
  • increased BP
  • decreased BP
  • pancreatitis
  • hypovolemia
  • hyperkalemia

Question 74

Question
Hypovolemia must be corrected prior to starting a SGLT-2 inhibitor
Answer
  • True
  • False

Question 75

Question
Increased risk of bladder cancer and bone fracture with [blank_start]Dapagliflozin (Farxiga)[blank_end]
Answer
  • Dapagliflozin (Farxiga)
  • Canagliflozin (Invokana)
  • Empagliflozin (Jardiance)

Question 76

Question
[blank_start]Empagliflozin (Jardiance)[blank_end] is assocaited with an increase in CV events
Answer
  • Empagliflozin (Jardiance)
  • Canagliflozin (Invokana)
  • Dapagliflozin (Farxiga)

Question 77

Question
[blank_start]Canagliflozin (Invokana)[blank_end] may be associated with an increase in lower extremity amputations
Answer
  • Canagliflozin (Invokana)
  • Dapagliflozin (Farxiga)
  • Empagliflozin (Jardiance)

Question 78

Question
Which drug classes target fasting BG only!
Answer
  • Biguanides
  • TZDs
  • SGLT-2
  • Amylinomimetics

Question 79

Question
Which drug classes targets post-prandial blood glucose only!
Answer
  • Biguanides
  • Sulfonylureas
  • Amylinomimetics
  • alpha-glucosidase inhibitors
  • dopamine agonist
  • DPP-4 inhibitors
  • meglitinides

Question 80

Question
What drug classes target BOTH fasting and postprandial BG levels?
Answer
  • Sulfonylureas
  • TZDs
  • SGLT-2 inhibitors
  • Bile acid sequestrants

Question 81

Question
GLP-1 agonist, Metformin, SGLT-2, Amylinmimetics all cause [blank_start]weight loss[blank_end]
Answer
  • weight loss
  • weight gain
  • weight neutral

Question 82

Question
Metformin, alpha-glucosidase inhibitors, DPP-IV inhibitors all cause [blank_start]weight gain[blank_end]
Answer
  • weight gain
  • weight loss
  • weight neutral

Question 83

Question
Suflonylureas, Meglitinides, insulins, and TZDs all cause [blank_start]weight loss[blank_end]
Answer
  • weight loss
  • weight gain
  • weight neutral

Question 84

Question
Which drug classes are high cost agents?
Answer
  • GLP-1
  • SGLT-2
  • DPP-IV
  • Insulins
  • Metformin
  • Sulfonylureas
  • TZDs

Question 85

Question
Which drugs classes are low cost agents?
Answer
  • Metformin
  • Sulfonylureas
  • DPP-IV
  • TZDs
  • GLP-1
  • SGLT-2
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