Enzymes: Non-competitive Inhibitors

Attach themselves to the [blank_start]enzyme[blank_end] at a binding [blank_start]site[blank_end] which is not the active site

It [blank_start]alters[blank_end] the shape of the enzyme and subsequently the [blank_start]active[blank_end] site to the extent which substrate molecules can no longer [blank_start]bond[blank_end], so the enzyme cannot function

Due to lack of c[blank_start]ompetition[blank_end], an i[blank_start]ncrease[blank_end] in substrate concentration does not reduce the effect of the i[blank_start]nhibitor[blank_end]