Quiz
Powder 2018
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1Because the quantity of drug formulated into tablets and capsules can be measured accurately, these systems are ideal for [blank_start]potent[blank_end] drugs
- Apotent
2[blank_start]Powders for Reconstitution[blank_end]:
- Immediately prior to use, oral powders are mixed in a beverage or apple sauce.
- Because these constituted products have
limited stability, they are required to have a
specified expiration date after constitution
and may require storage in a refrigerator.- APowders for Reconstitution
3Bulk oral powders are limited to relatively non-potent drugs such as [blank_start]laxatives[blank_end], [blank_start]antacids[blank_end], dietary supplements, and certain analgesics that the patient may safely measure by the teaspoonful or capful.
- Alaxatives
- Bantacids
4Reducing the particle size of a powder will result in a uniform distribution of particle sizes. The process of reducing the particle size is called [blank_start]comminution[blank_end]
- Acomminution
5In compounding, there are 3 methods of comminution:
1) [blank_start]Trituration[blank_end]
2) [blank_start]Pulverization[blank_end] by Intervention
3) [blank_start]Levigation[blank_end]- ATrituration
- BPulverization
- CLevigation
6Sieving is most suitable where a majority of the particles are larger than about [blank_start]75[blank_end] mcm
- A75
7Very Coarse > [blank_start]1000[blank_end]
Coarse [blank_start]355–1000[blank_end]
Moderately Fine [blank_start]180–355[blank_end]
Fine [blank_start]125–180[blank_end]
Very Fine [blank_start]90–125[blank_end]- A1000
- B355–1000
- C180–355
- D125–180
- E90–125
8[blank_start]Optical microscopy[blank_end] for particle characterization can generally be applied to particles 1 μm and greater. Useful for characterizing particles that are not spherical.
- AOptical microscopy
9[blank_start]Feret's[blank_end] Diameter— The distance between imaginary parallel lines tangent to a randomly oriented particle and perpendicular to the ocular scale.
- AFeret's
10[blank_start]Martin's[blank_end] Diameter— The diameter of the particle at the point that divides a randomly oriented particle into two equal projected areas.
- AMartin's
11[blank_start]Projected Area[blank_end] Diameter— The diameter of a circle that has the
same projected area as the particle.- AProjected Area
12Commonly used descriptions of particle shape.
• [blank_start]Acicular[blank_end]— Slender, needle-like particle of similar width and thickness.
• [blank_start]Columnar[blank_end]— Long, thin particle with a width and thickness that are greater than those of an acicular particle.
• [blank_start]Flake[blank_end]— Thin, flat particle of similar length and width.
• [blank_start]Plate[blank_end]— Flat particles of similar length and width but with greater thickness than flakes.
• [blank_start]Lath[blank_end]— Long, thin, and blade-like particle.
• [blank_start]Equant[blank_end]— Particles of similar length, width, and thickness; both cubical and spherical particles are included- AAcicular
- BColumnar
- CFlake
- DPlate
- ELath
- FEquant
- GColumnar
- HAcicular
- IFlake
- JPlate
- KLath
- LEquant
- MFlake
- NAcicular
- OColumnar
- PLath
- QEquant
- RPlate
- SPlate
- TAcicular
- UColumnar
- VFlake
- WLath
- XEquant
- YLath
- ZAcicular
- AAColumnar
- ABFlake
- ACPlate
- ADEquant
- AEEquant
- AFAcicular
- AGColumnar
- AHFlake
- AIPlate
- AJLath
13– [blank_start]Lamellar[blank_end]— Stacked plates.
– [blank_start]Aggregate[blank_end]— Mass of adhered particles.
– [blank_start]Agglomerate[blank_end]— Fused or cemented particles.
– [blank_start]Conglomerate[blank_end]— Mixture of two or more types of particles.
– [blank_start]Spherulite[blank_end]— Radial cluster.
– [blank_start]Drusy[blank_end]— Particle covered with tiny particles.- ALamellar
- BAggregate
- CAgglomerate
- DConglomerate
- ESpherulite
- FDrusy
- GAggregate
- HLamellar
- IAgglomerate
- JConglomerate
- KSpherulite
- LDrusy
- MAgglomerate
- NLamellar
- OAggregate
- PConglomerate
- QSpherulite
- RDrusy
- SLamellar
- TAggregate
- UAgglomerate
- VConglomerate
- WSpherulite
- XDrusy
- YSpherulite
- ZLamellar
- AAAggregate
- ABAgglomerate
- ACConglomerate
- ADDrusy
- AEDrusy
- AFLamellar
- AGAggregate
- AHAgglomerate
- AIConglomerate
- AJSpherulite
14[blank_start]True volume[blank_end]: the space occupied by the powder exclusive of
spaces greater than the intramolecular space- ATrue volume
15[blank_start]bulk volume[blank_end]: the volume occupied by a selected weight of a powder
- Abulk volume
16[blank_start]apparent density[blank_end] : Weight of sample/ Vbulk
- Aapparent density
17[blank_start]true density[blank_end] : Weight of sample/ Vtrue
- Atrue density
18The granular density includes contributions to particle volume from open pores smaller than some limiting size.
- Granular density will never be [blank_start]greater[blank_end] than true density- Agreater
19The [blank_start]pycnometric density[blank_end] equals the true density unless the material contains impenetrable voids, or sealed pores, that are inaccessible to the gas used in the pycnometer.
- Apycnometric density
20[blank_start]Geometric dilution[blank_end]:
•blending two or more powders of unequal amounts
• ensure that small quantities of ingredients such as potent drug are uniformly distributed in the mixture
• trituration method- AGeometric dilution
Informationen
- Beschreibung
- • Give general explanation about the instruments for particle size determination, etc (application, theory, etc) •Give general explanation about the instruments for particle density determination, etc (application, theory, etc) •Demonstrate knowledge about USP methods to characterize powder properties •Know compounding techniques • Describe appropriate uses of pharmaceutical powders and granules.
- Autor
- Crystal Yu
- Sprache
- English
- Aufrufe
- 82
- Schlagwörter
- Bewertung
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