Flussdiagramm
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Inhalt des Flussdiagramms
ligand binds its membrane G-linked protein receptor
activation of a G protein: Gq
Gq activates a phospholipase C (called C beta)
generates both IP3 and diacylglycerol (DAG)
IP3 diffuses thro the cytosol
IP3 binds to IP3 receptor channel (ligand-gated calcium channel)
Calcium is released into cytosol
Calcium & DAG activate members of the protein kinase C (PKC) family
PKC phosphorylates ser & thr on a variety of target proteins
DAG remains in membrane where it activates protein kinase C
displacement of GDP by GTP & dissociation of sub-units
GTP-G aplha complex binds to phospholipase C and activates it
PIP2 cleaved
DAG & IP3 signaling
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- Flussdiagramm am Ohne Titel, erstellt von Steve Iype am 29/11/2019.
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- Steve Iype
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