GPCR signalling and structure

GPCR signalling and structure

1. Structure

   • Provides clues to complexity of signalling
     • And hope for development of new theraputics
   • Comparison of four GPCR structures

2. GPCR engineering

   • Yields high resolution structural insights into receptor function
     • Why did it take 15+ years to crystalize and solve a GPCR structure?
   • Rhodopsin vs other GPCR's

3. GPCR structure predicts

   • Complexity in function
   • Agonist biased signalling

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