CPT-1

CPT-1

1. Transports long chain fatty acids across the mitochondrial membrane

2. Inhibitors of CPT-1

   • Increased levels of malonyl CoA
     • Occurs when concentrations of acetyl CoA in cytoplasm are increased
       • Result of increased CHO availability
     • Exercise elevates cytoplasmic AMPK which inhibits ACC = Less malonyl CoA
       • As duration of exercise increases more FA liberated, AMPK activated CPT-1 = more oxidation of FA

3. As duration of exercise increases more FA liberated, AMPK activated CPT-1 = more oxidation of FA