Mindmap

NTDs

sam.hilton Englisch

Mind map: NTDs neural tube defects

Inhalt der Mindmap

NTDs

Formation of CNS
- Formation
- Shaping
  - PCP pathway
    - Cell fate
    - Cytoskeletal changes
- Bending and fusion
  - Hingepoints
Types of NTD
- Spina bifida
  - pathogenesis
  - Hydroencephaly
- Enter text here
Predisposing factors
- Anti-epilepsy
- Hyperthemia
- Hypervitaminosia
- Diabetes
  - Inositol
- Fumanosin
- Folic acid related
  - MTHFR
  - Autoantibodies against FR
Mouse models
- Folate sensitive
  - Cited2
  - Splotch 2h
- Folate resistant
  - ct/ct
    - Eyelash
    - grhl3 cDNA
    - change cell prolif rates
      - reduce NT
        cell division inhibitors
      - Increase NC
        Retinoic acid
    - Inositol
      - Effects
        in vivo
        in vitro
- Diabetic
  - SELH/Bc