Yasser is falling behind

Yasser is falling behind

1. Slow growth rate

   • Causes
     • systemic
     • Endocrine
       • Genetics
         • Pregnancy environment

2. Growth hormone deficiency

   • Pathology
     • Physical examination
       • Height
         • Weight
           • Body proportions
       • Investigations
         • Blood Tests
           • Imaging
     • Management
       • GH deficiency
         • GHRH (sermorelir)
           • rGH (neutron)
             • rIGF (mecasermine)
       • GH Excess
         • Somatostatin
           • GH receptor antagonists
   • Causes
     • Congenital
       • initiate the hypothalamus or its connection to the pituitary gland
     • Acquired
       • head trauma
       • radiation therapy
       • timor in the hypothalamus or pituitary
   • Signs & symptoms
     • delayed puberty
     • Short stature
     • chubby body build
     • delayed tooth development

3. Growth Chart

   • Growth sprouts

4. Physiology

5. Pathology of Pituitary Gland

   • Hyperpituitarism
     • The most common cause of hyperpituitarism is an adenoma arising in the anterior lobe. Other less common causes include hyperplasia and carcinomas of the anterior pituitary
     • Pharmacological treatment: 1. somatostatin receptor agonists (also known as somatostatin receptor ligands (SRLs) or somatostatin analogues). 2. dopamine analogues. 3. GH receptor antagonists.
   • Pituitary Adenomas
     • Pituitary adenomas are benign neoplasms of the anterior lobe of the pituitary and are often associated with excess secretion of pituitary hormones treated by surgical resection. medical therapy, and radiation therapy.
   • Hypopituitarism
     • Pharmacological treatment: 1. Somatropin. 2. Mecasermin..etc.
     • Causes
       • IATROGENIC HYPOPITUITARISM
       • PITUITARY TUMORS
       • TRUAMA + INFILTRATIVE DISSEASES
       • ISCHAEMIC NECROSIS OF THE PITUITARY ELAND
       • PITUITARY APOPLEXY

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