Carboxylic Acid Derivatives

Carboxylic Acid Derivatives

1. OH replaced by other groups

2. Acyl Chloride

   • Very reactive
   • + alcohol/phenols = Esters at rtp.
   • + amines = amides at rtp
   • + water = carboxylic acid + HCl
   • acylating agent

3. Acid Anhydride

   • more reactive than COOH
     • + phenols = esters
     • less than acyl chlorides
   • vigorous ethanoylating agent
   • made by eliminating water from COOH molecules
   • used instead of acyl chlorides
     • less dangerous
     • less expensive
     • less toxic
   • acylating agent

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