Liver Function Test

Liver Function Test

1. High serum Bilirubin

   • High Conjugated
     • Bc excretion problem
       • Super high level/time
         • Bilirubin delta (covalent to albumin)
       • inherited
         • Rotor Syndrome
         • Dubin-Johnson
     • Obstructive jaundice
       • pale stool
       • no urobilinogen in urine
   • High Unconjugated
     • Inherited
       • UGT defect
         • Gilberts
         • Crigler-Najjar
     • Pre-hepatic hemolysis
       • normal urine color (Bu bound to albumin)
   • Mixed Bu and Bc
     • hepatocellular injury
       • hepatocellular jaundice
         • slightly darkened urine

2. high ALT and AST

   • hepatocellular necrosis

3. low ALT

   • Advanced Cirrhosis