Zusammenfassung der Ressource
Cell Division
- CDK
- cell cycle regulator
- regulated by:
- Cyclin
- phosphorylation
- CDK inhibitors
- cyclins
- tell CDK what to Phosporylate
- have specific binding sites for CDK
- p53
- transcription factor
- regulator of response to DNA damage
- if damaged, p53 is up-regulated
- decides if damage will be repaired
- if not cell undergoes apoptosis
- cell death
- requirements
- cyclin bound to CDK
- Rb phosphorylated
- E2F bound to DNA