Zusammenfassung der Ressource
Competitive and
Noncompetitive Inhibitors
- Competitive Inhibitors
- mimic the substrate and compete for the
binding to the active site
- effectiveness = depends on affinities for that site.
- Km is increased in a double reciprocal plot
- Noncompetitive Inhibitors
- bind at a site other than the active one which
means no competition with the substrate
- Example: covalent modififcation -
the action of aspirin in acylating
cyclooxygenase at a serine at the
active site
- Uncompetitive inhibition
- inhibitor binds to the ES complex only