Role of 2,3-biphosphoglycerate in hemoglobin function

kathrynmoar
Mind Map by , created almost 6 years ago

Topic 3 - Metabolism Mind Map on Role of 2,3-biphosphoglycerate in hemoglobin function, created by kathrynmoar on 10/26/2013.

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kathrynmoar
Created by kathrynmoar almost 6 years ago
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Role of 2,3-biphosphoglycerate in hemoglobin function
1 BPG binds to the deoxygenated form of hemoglobin but not the oxygenated form.
1.1 presence = equilibrium tipped towards the deoxygenated form.
2 oxygenated hemoglobin = BPG can no longer fit into the cavity
3 importance = in embryos. there must be a transfer of oxygen from the mother's hemoglobin to the empbyo
3.1 fetal hemoglobin = beta chain is replaced by a gamma chain.
3.2 fetal chain has one less posiitive charge in BPG binding cavity than adult hemoglobin and binds BPG less tightly
3.3 fetal hemoglobin has a higher oxygen affinity than the adult form

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