Sickle Cell Disease

Sickle Cell Disease

1. genetic disorder

   • autosomal recessive
   • abnormal hemoglobin
     • causes chronic hemolytic anemia
   • Life expectancies mid 40s
     • better care increases life expectancy
   • Incidence
     • 1:400-600 blacks
     • 1:1000 Hispanics
     • also India, Middle East , and Mediterranean individuals

2. Disease Complications

   • infarction of lungs, kidneys, spleen, and bones
   • Painful Leg Ulcers
   • dactylitis
   • Priapism
   • Renal failure
   • increased risk of infection
     • pneumococcal
     • salmonella osteomyelitis

3. Diagnosis