Zusammenfassung der Ressource
Lipid Raft
- Fonctions
- Transduction of signal
- Rcp + L
- Recruitment of proteins
- Endocytosis (of receptors)
- CD44 + LR
- Ac. hyaluronic
- Internalisation (via Calveolin)
- Lysosome
- RCP degrated
- Cellular
polarisation
- Apical MB : GPI proteins
- Basal MB : MB proteins
- Viral budding
- Hemagglutin
- Structure
- 35-40% in plasma MB
- Outer layer
- Cytosolic face
- Calveolin
- Stabilisation of LR
- Composition
- Cholesterol
- +++
- MB rigidity
- Glycoshingolipids
- Shyngosine
- Outer leaflet of the lipid bilayer
- When @ cell surface
- Intercellular communication
- Important role in cell adhesion mecanisms
- When associated with LR
- Signal transduction
- Receptor for pathogens
- Addressing proteins
- Proteins
- GPI-anchored proteins
- Associated to the MB
- Biosynthesis of GPI-proteins
- PICTURE
- MB proteins
- Extracellular domain
- EGF receptor
- Area rich in cystein
- Transmembrane domain
- Ex : for virus enveloppe
- Hemagglutin
- HA1 : attachement viral particule
- HA2 : release of the virus' contents
- Intracellular Domain
- For LR adressing
- Microdomaine formation via linking between
- Cholesterol
- Glycosphingolipids
- Detergent insoluble