The link reaction

Converts pyruvate (from glycolysis) to acetate. NAD is reduced.
1. Decarboxylation and dehydrogenation are enzyme catalysed reactions (pyruvate is substrate)
  1. Pyruvate dehydrogenase removes H atoms; pyruvate decarboxylase removes a carboxyl group
  2. Coenzyme NAD accepts the H atoms; coenzyme A (CoA) accepts the acetate > acetyl CoA
Takes place in the matrix, so pyruvate has to be transported into mitochondria from the cytoplasm
2 pyruvate + 2 NAD+ (oxidised) + 2 CoA ------> 2 CO2 + 2 reduced NAD + 2 acetyl CoA
1. No ATP produced, but each NADH carrying 2 H atoms - will take to inner mitochondrial membrane where H atoms used to produce ATP during oxidative phosphorylation
2. 2 molecules of everything because two molecules of pyruvate derived from each glucose molecule
Pyruvate is 3C, acetate is 2C, acetyl CoA is 2C

Zusammenfassung der Ressource

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