Lymphatic System and Immunity

Lymphatic System and Immunity

1. recirculates interstitial fluid

2. Components of Lymphatic System

   • Lymphatic Capillaries
   • Lymphatic Vessels
   • Lymph Nodes
   • Lymphatic Trunks
   • Lymphatic Ducts
   • Primary Lymph Organs
     • Thymus - T-Cells are formed
       • what is inveloom?
       • The thymus is where t and b cells mature
       • Hangs over heart, largest at puberty, shrinks as we age, makes t-cells, immunocompitent
     • Red Bone Marrow - B- cells
   • Secondary Lymph Organs and Tissues
     • Spleen
       • holds platelets- w/o spleen clotting can become problematic
       • White and red pulp; platelets are stored here; white-lymphatic tissue; old rbc's are destroyed here
     • Lymph Nodes
       • Scattered along lymphatic vessels; superficial and deep; serve as filters

3. Lymph- Clear, Milky interstitial Fluid in the lymphatic system

4. lymph moves the same way that blood moves-body facilitation

   • lymph fluid moves by respitory pump

5. Afferent Vessels- going in

   • There are more Afferent vessels then efferent, this is to give the B and T cells a chance to attack.

6. Efferent Vessels - going out

   • Less of these, and they leave the lymph node through the hilum (indentation)

7. Immune Response

   • Innate
     • We are born with this type of immunity, we get this from Mom
     • At birth we have non-specific and non adaptive immunity (immune response), this includes 1st and 2nd line of defense pgs 886-888 in text
   • Adaptive (aquired)
     • two types, cell mediated or antibody mediated, both are gained through vaccines
     • Describes the ability of the body to adapt defenses against antigens of specific bacteria, viruses, foreign tissue.....even toxins
     • Cell mediated
     • Antibody Mediated

8. right side is lymphatic; left side is thoracic

   • the sides of the lymphatic system

9. Lacteals

   • Specialized lymphatic capillaries

10. chemotaxis

    • wandering macrophages

11. Natural Killer Cells

    • "Terminator" cells - goes after cancer cells without hesitation - the theory is that we are born with only so many

12. Interferons

    • The beta ones are used to treat and to slow the progress of MS

13. Phagocytosis

    • There are 5 steps: Chemotaxis, Adherence, Ingestion, Digestion, Killing