Quiz
PHSI3012 01-1 Cell Proliferation
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Fragen in diesem Quiz (14)
1What is the difference between cell growth and cell proliferation?
- ACell growth = increase in ONE cell's mass/size; Cell proliferation = increase in cell numbers.
- BCell growth = increase in cell numbers; Cell proliferation = increase in ONE cell's mass/size.
- CNo meaningful distinction.
(/ distinction without substantial difference)
(/ fuck all)
2Which of the following is true?
- AControl of cell proliferation is intrinsically linked to cell growth.
- BControl of cell growth is intrinsically linked to cell proliferation.
3The order of the rough phases of the cell cycle are as follows:
G1 > [blank_start]_____[blank_end] > [blank_start]_____[blank_end] > [blank_start]_____[blank_end] > [blank_start]_____[blank_end] (then back to G1 again)- AS
- BG2
- CM
- DCytokinesis
4G1 phase stands for, and involves, what?
- AGrowth phase
- BGap phase
- CCell growth
- DMonitoring
- EMitosis
5G2 phase stands for, and involves, what?
- AGrowth phase
- BGap phase
- CCell growth
- DMonitoring
- EMitosis
6S phase stands for, and involves, what?
- ADNA synthesis
- BSelectivity
- CCell growth
- DMitosis
- EStretching
7M phase stands for, and involves, what?
- AMitosis
- BMeiosis
- CMonitoring
- DDNA synthesis
- ECell division
8Cdks (Cyclin-Dependent KinaseS) are regulated by:
- ACyclins
- BPhosphorylation
- CBoth of the above
- D[none of the above]
9Mitogens are:
- AThings that stimulate cell division (e.g. hormones, cytokines).
- BStimulate migration.
10Disordered signaling in cancer.
Many cancer-critical genes (oncogenes or tumour-suppressor genes) regulate cell growth and proliferation.
e.g. a mutation may lead to independence from mitogen-dependence.
Acquiring the ability to synthesise mitogens (resulting in autocrine stimulation) is one way this can happen. Some examples of this are:- APDGF, TGFα - glioblastomas & osteosarcoma
- BEGF-R/erbB (epidermal growth factor receptor); HER2 (human epidermal growth factor receptor)
11Disordered signaling in cancer.
Many cancer-critical genes (oncogenes or tumour-suppressor genes) regulate cell growth and proliferation.
e.g. a mutation may lead to independence from mitogen-dependence.
Constitutive expression of their receptors (resulting in increased sensitivity?) is one way this can happen. Some examples of this are:- APDGF, TGFα - glioblastomas & osteosarcoma
- BEGF-R/erbB (epidermal growth factor receptor); HER2 (human epidermal growth factor receptor)
12HER2 (Human Epidermal growth factor Receptor) mutations are present in:
- AOverexpressed in breast cancer.
- BOverexpressed in stomach, brain, and breast cancer.
- CAbnormally present in glioblastomas and osteosarcoma.
13EGF-R / erbB (Epidermal Growth Factor Receptor) and cancer...
- AUp-regulated in stomach, brain, and breast cancer.
- BUp-regulated in breast cancer.
- CAbnormally present in gliobastomas & osteosarcoma.
14True or false: Mitogens [usually?] act through the ras/raf/ERK cascade.
- ARichtig
- BFalsch
Informationen
- Beschreibung
- Learning objectives: * Understand the difference between cell growth and proliferation * Describe the major events of the cell cycle * Appreciate the roles of cyclins and cyclin-dependent kinases in regulating cell cycle progression * Provide examples of disordered signaling in cancer * Describe checkpoints and how they regulate the correct expression of the cell cycle * Understand the role of apoptosis in preventing inappropriate cell proliferation
- Autor
- Gelöschter Nutzer
- Sprache
- English
- Aufrufe
- 51
- Verlauf
- Erstellt am 18 Nov 2017 · aktualisiert am 18 Nov 2017
- Schlagwörter
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