Vancomycin Dosing

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Staphylcoccus Aureus(MIC=1)

AUC;MIC> 400

trough 15 mcg/mL

normal renal function

15-20 mg/kg Q8-12H

Renal dysfunction

Age < 40 and Scr is <1.4, interval= Q8H

Age 40- 65 and has a Scr <1.4, interval = Q12h

Age > 65 or Scr is >1.4 (regardless of age), interval = Q24h

CVVH Dialysis, 10-15 mg/kg Q24H

Adjusting Vanco Levels

can adjust proportionally

Current dose/Cmin(actual)=x(new dose)/Cmin(desired)

Dosing based on Kinetics

Elimination rate constant (kel): Vancomycin kel = (0.00083 x CrCl) + 0.0044

t1/2 = 0.693/kel

Calculation of trough concentration at steady state (Cpminss)

Cpminss = (Cpmaxss)(e-Kel (Τ-t’))

MD = maintenance dose

MD = (Cpmax)(Vd)(t')(Kel) x (1-e^(-KelΤ))

(1-e^(-Kelt’))

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